910298-60-1

Basic information

• Product Name: O-DeMethyl Vandetanib
• Synonyms: O-DeMethyl Vandetanib;4-[(4-BroMo-2-fluorophenyl)aMino]-7-[(1-Methyl-4-piperidinyl)Methoxy]-6-quinazolinol;O-Desmethyl Vandetanib
• CAS NO: 910298-60-1
• Molecular Formula: C21H22BrFN4O2
• Molecular Weight: 461.3273832
• Product Categories: Aromatics;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 910298-60-1.mol
• Article Data: 1

Chemical Properties

• Melting Point: 223-225 °C
• Boiling Point: 554.0±50.0 °C(Predicted)
• Appearance: /
• Density: 1.476±0.06 g/cm3(Predicted)
• PKA: 8.18±0.40(Predicted)
• CAS DataBase Reference: O-DeMethyl Vandetanib(CAS DataBase Reference)
• NIST Chemistry Reference: O-DeMethyl Vandetanib(910298-60-1)
• EPA Substance Registry System: O-DeMethyl Vandetanib(910298-60-1)

Safety Data

• Hazardous Substances Data: 910298-60-1(Hazardous Substances Data)

Usage

Uses

A metabolite of Vandetanib (V097100).

Upstream product

• 338992-20-4 4-(((4-((4-bromo-2-fluorophenyl)amino)-6-methoxyquinazolin-7-yl)oxy)methyl)piperidine-1-carboxylic acid tert-butyl ester 
• 338992-12-4 N-Desmethylvandetanib 
• 443913-73-3 vandetanib 
• 768350-54-5 7-(benzyloxy)-N-(4-bromo-2-fluorophenyl)-6-methoxyquinazolin-4-amine hydrochloride 
• 196603-96-0 4-(4-bromo-2-fluorophenylamino)-7-hydroxy-6-methoxyquinazoline 
• 162364-72-9 7-benzyloxy-4-chloro-6-methoxyquinazoline 
• 367-24-8 4-bromo-2-fluoroaniline 

Relevant articles and documents

Radiosynthesis of [11C]Vandetanib and [11C]chloro- Vandetanib as new potential PET agents for imaging of VEGFR in cancer

Vandetanib (ZD6474) and its chlorine analogue chloro-Vandetanib are potent and selective vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitors with low nanomolar IC50 values. [ 11C]Vandetanib and [11C]chloro-Vandetanib, new potential PET agents for imaging of VEGFR in cancer, were first designed, synthesized and labeled at nitrogen and oxygen positions from their corresponding N- and O-des-methylated precursors, in 40-50% decay corrected radiochemical yield and 370-555 GBq/μmol specific activity at end of bombardment (EOB).