19677-37-3

Basic information

• Product Name: DIETHYL 4-CHLOROPHENYL MALONATE
• Synonyms: DIETHYL 4-CHLOROPHENYL MALONATE;RARECHEM AL BI 0611;2-(4-Chlorophenyl)-malonic acid diethylester;4-chlorophenyl 1-ethyl 2-ethylpropanedioate;2-(4-chlorophenyl)Malonic acid;Diethyl 2-(4-chlorophenyl)Malonate;PROPANEDIOIC ACID, 2-(4-CHLOROPHENYL)-, 1,3-DIETHYL ESTER;Diethyl (p-chlorophenyl)malonate
• CAS NO: 19677-37-3
• Molecular Formula: C₁₃H₁₅ClO₄
• Molecular Weight: 270.71
• Mol File: 19677-37-3.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 334.1°Cat760mmHg
• Flash Point: 125.2°C
• Appearance: /
• Density: 1.206g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 11.06±0.46(Predicted)
• CAS DataBase Reference: DIETHYL 4-CHLOROPHENYL MALONATE(CAS DataBase Reference)
• NIST Chemistry Reference: DIETHYL 4-CHLOROPHENYL MALONATE(19677-37-3)
• EPA Substance Registry System: DIETHYL 4-CHLOROPHENYL MALONATE(19677-37-3)

Safety Data

• Hazardous Substances Data: 19677-37-3(Hazardous Substances Data)

Usage

General Description

Diethyl 4-Chlorophenyl Malonate is a chemical compound used primarily in the pharmaceutical industry, often as an intermediate for producing other substances. Its chemical formula is C13H14ClNO4. As a colourless liquid, it is relatively stable under standard conditions, but may decompose under the influence of heat. While it may pose a slight health risk in cases of inhalation or direct contact, it generally has a low level of toxicity. Additionally, it is important to store it properly to avoid risk of fire or explosion in conditions of high heat or reactive agents. It's also used in scientific research due to its potentially useful properties.

Upstream product

• 64-17-5 ethanol 
• 147795-56-0 ethyl 2-(4-chlorophenyl)-2-cyanoacetate 
• 106-46-7 para-dichlorobenzene 
• 105-53-3 diethyl malonate 
• 14062-24-9 4-chloro-benzeneacetic acid, ethyl ester 
• 105-58-8 Diethyl carbonate 
• 637-87-6 1-Chloro-4-iodobenzene 
• 1878-66-6 4-chlorophenylacetic Acid 
• 140-53-4 p-chlorobenzyl cyanide 
• 86409-62-3 tricarbonyl(1,4-dichlorobenzene)chromium⁽⁰⁾ 
• 106-39-8 bromochlorobenzene 
• 623-49-4 ethyl cyanoformate 
• 19213-72-0 ethyl 1-imidazolecarboxylate 
• 7519-91-7 tris(4-chlorophenyl)boroxine 

Downstream Products

• 58007-14-0 4-(4-chloro-phenyl)-isoxazolidine-3,5-dione 
• 106367-56-0 4-(p-methoxyphenyl)-3,5-dihydroxypyrazole 
• 199436-87-8 2-(4-Chloro-phenyl)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-malonic acid diethyl ester 
• 199437-08-6 2-(4-Chloro-phenyl)-2-(2-cyano-ethyl)-malonic acid diethyl ester 
• 92494-41-2 Cyan-methyl-(4-chlor-phenyl)-malonsaeure-diaethylester 
• 199436-98-1 2-(4-Chloro-phenyl)-3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propionyl chloride 
• 199436-96-9 N-[2-Carboxy-2-(4-chloro-phenyl)-ethyl]-phthalamic acid 
• 199436-99-2 2-(4-Chloro-phenyl)-3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-N-hydroxy-propionamide 
• 69308-37-8 (R)-baclofen 
• 159248-22-3 Acetic acid (S)-2-(4-chloro-phenyl)-3-hydroxy-propyl ester 
• 159156-89-5 4-azido-3-(p-chlorophenyl)butyronitrile 
• 159156-86-2 4-acetoxy-3-(p-chlorophenyl)butyronitrile 

Relevant articles and documents

Production process of 2-methyl-2-(4-chlorphenyl)-1, 3-propylene glycol

The invention discloses a production process of 2-methyl-2-(4-chlorphenyl)-1, 3-propylene glycol. The process comprises the following steps: taking p-chloroiodobenzene and diethyl malonate as initialraw materials; firstly, subjecting the p-chloroiodobenzene and diethyl malonate to coupling reaction to prepare a compound 3; carrying out alkylation reaction on the compound 3 and methyl iodide to obtain a compound 4; reacting the compound 4 with lithium aluminum hydride to obtain a 2-methyl-2-(4-chlorphenyl)-1, 3-propylene glycol crude product; and finally, subjecting the 2-methyl-2-(4-chlorphenyl)-1, 3-propylene glycol to a recrystallization procedure, thus obtaining the target product 2-methyl-2-(4-chlorphenyl)-1, 3-propylene glycol.

Oxidative Coupling of Aryl Boron Reagents with sp3-Carbon Nucleophiles: the Enolate Chan-Evans-Lam Reaction

Reported is a versatile new oxidative method for the arylation of activated methylene species. Under mild reaction conditions (RT to 40 C), Cu(OTf)2 mediates the selective coupling of functionalized aryl boron species with a variety of stabilized sp3-nucl

An efficient method for the preparation of mono α-aryl derivatives of diethyl malonate and ethyl cyanoacetate using ethyl-1-imidazole carbamate (EImC)

An efficient method for the synthesis of mono α-aryl derivatives of diethyl malonate and ethyl cyanoacetate using ethyl-1-imidazole carbamate (EImC) has been described. Using this method many sterically hindered and highly substituted mono α-aryl derivatives of diethyl malonate and ethyl cyanoacetate were synthesized in high yield.