196952-70-2

Basic information

• Product Name: 2,3-Butadien-1-one, 1-(4-methoxyphenyl)-
• CAS NO: 196952-70-2
• Molecular Formula: C11H10O2
• Molecular Weight: 174.199
• Mol File: 196952-70-2.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: 2,3-Butadien-1-one, 1-(4-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-Butadien-1-one, 1-(4-methoxyphenyl)-(196952-70-2)
• EPA Substance Registry System: 2,3-Butadien-1-one, 1-(4-methoxyphenyl)-(196952-70-2)

Safety Data

• Hazardous Substances Data: 196952-70-2(Hazardous Substances Data)

Usage

General Description

2,3-Butadien-1-one, 1-(4-methoxyphenyl)- is a chemical compound with a molecular formula C11H10O2. It is also known by the chemical name 4-Methoxyphenacylidenemalononitrile. 2,3-Butadien-1-one, 1-(4-methoxyphenyl)- is a yellow crystalline powder that is insoluble in water but soluble in organic solvents. It is commonly used as a reagent in organic synthesis and also as a fluorescent probe in biological research. 2,3-Butadien-1-one, 1-(4-methoxyphenyl)- is a versatile compound with a variety of applications in the chemical and biological fields.

Upstream product

• 83816-48-2 1-(4-methoxyphenyl)but-3-yn-1-ol 
• 14271-83-1 4-methoxybenzoyl cyanide 
• 106-96-7 propargyl bromide 
• 52898-49-4 4,N-dimethoxy-N-methylbenzamide 
• 123-11-5 4-methoxy-benzaldehyde 
• 1250880-92-2 C₁₁H₁₀O₂ 
• 146983-99-5 1-(4-methoxylphenyl)buta-2,3-dien-1-ol 

Downstream Products

• 1258702-17-8 (E)-ethyl 4-bromo-6-(4-methoxyphenyl)-6-oxo-2-(tosylamino)hex-4-enoate 
• 1332524-96-5 (E)-2-benzyl-5-(4-methoxyphenyl)-3-methyl-5-oxopent-2-enenitrile 
• 1332524-94-3 (Z)-2-benzyl-5-(4-methoxyphenyl)-3-methyl-5-oxopent-2-enenitrile 
• 1332525-00-4 (E)-2-allyl-5-(4-methoxyphenyl)-3-methyl-5-oxopent-2-enenitrile 
• 1332524-98-7 (Z)-2-allyl-5-(4-methoxyphenyl)-3-methyl-5-oxopent-2-enenitrile 
• 1332524-79-4 (Z)-5-(4-methoxyphenyl)-2,3-dimethyl-5-oxopent-2-enenitrile 
• 1332524-81-8 (E)-5-(4-methoxyphenyl)-2,3-dimethyl-5-oxopent-2-enenitrile 
• 1332524-44-3 3-cyano-2,6-dimethyl-1-(4-methoxybenzoyl)-4-(4-methoxyphenyl)benzene 
• 1580528-80-8 7-(4-methoxyphenyl)-5-methylpyrazolo[1,5-a]pyrimidine 
• 1580529-01-6 2-cyclopropyl-7-(4-methoxyphenyl)-5-methylpyrazolo[1,5-a]pyrimidine 
• 1590402-43-9 (3-benzoyl-2-methylindolizin-1-yl)(3-bromophenyl)methanone 
• 23263-96-9 3-methyl-5-p-methoxyphenyl-1-hydropyrazole 
• 4211-85-2 5-(4-methoxyphenyl)-3-methylisoxazole 

Relevant articles and documents

Allenone-Mediated Racemization/Epimerization-Free Peptide Bond Formation and Its Application in Peptide Synthesis

Allenone has been identified as a highly effective peptide coupling reagent for the first time. The peptide bond was formed with an α-carbonyl vinyl ester as the key intermediate, the formation and subsequent aminolysis of which proceed spontaneously in a racemization-/epimerization-free manner. The allenone coupling reagent not only is effective for the synthesis of simple amides and dipeptides but is also amenable to peptide fragment condensation and solid-phase peptide synthesis (SPPS). The robustness of the allenone-mediated peptide bond formation was showcased incisively by the synthesis of carfilzomib, which involved a rare racemization-/epimerization-free N to C peptide elongation strategy. Furthermore, the successful synthesis of the model difficult peptide ACP (65-74) on a solid support suggested that this method was compatible with SPPS. This method combines the advantages of conventional active esters and coupling reagents, while overcoming the disadvantages of both strategies. Thus, this allenone-mediated peptide bond formation strategy represents a disruptive innovation in peptide synthesis.

Base-promoted direct synthesis of functionalized: N -arylindoles via the cascade reactions of allenic ketones with indoles

A convenient Cs2CO3-promoted cascade benzannulation reaction of allenic ketones with indoles was achieved for the synthesis of functionalized N-arylindole derivatives under transition-metal-free conditions. A series of readily available starting materials can undergo the process successfully. It represents a practical method for the construction of N-arylindole scaffolds with high atom economy.

Diverging Pathways in the Activation of Allenes with Lewis Acids and Bases: Addition, 1,2-Carboboration, and Cyclization

The reactions of allenes with frustrated (or cooperative) Lewis acid/base pairs result in the 1,4-addition of the base pair to the allene. The reactions of allenyl ketones and esters just in the presence of the strong Lewis acid B(C6F5/su