19725-26-9

Basic information

• Product Name: 3-(4-methoxyphenyl)piperidine
• Synonyms: 3-(4-methoxyphenyl)piperidine;Piperidine, 3-(4-methoxyphenyl)-
• CAS NO: 19725-26-9
• Molecular Formula: C₁₂H₁₇NO
• Molecular Weight: 191.26948
• Mol File: 19725-26-9.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(4-methoxyphenyl)piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-methoxyphenyl)piperidine(19725-26-9)
• EPA Substance Registry System: 3-(4-methoxyphenyl)piperidine(19725-26-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 19725-26-9(Hazardous Substances Data)

Usage

General Description

3-(4-methoxyphenyl)piperidine, also known as MOPPP, is a chemical compound that belongs to the family of piperidines. It is a white crystalline solid and is commonly used in research as a precursor in the synthesis of other chemical compounds. MOPPP has been identified as a potential drug candidate for the treatment of various medical conditions, including Parkinson's disease and attention deficit hyperactivity disorder (ADHD). However, due to its potential for abuse and dependence, it is classified as a controlled substance in many countries. MOPPP has also gained notoriety as a key ingredient in the synthesis of various illegal drugs, particularly synthetic cathinones, which are known for their stimulant and hallucinogenic effects.

Upstream product

• 19724-82-4 5-(4-methoxy-phenyl)-piperidin-2-one 
• 5958-02-1 3-(4-methoxyphenyl)pyridine 
• 906360-19-8 1-methanesulfonyl-3-(4-methoxy-phenyl)-piperidine 
• 906360-23-4 3-(4-methoxyphenyl)-1-p-toluenesulfonylpiperidine 
• 6859-99-0 3-hydroxypiperazine 
• 444606-08-0 1-(methylsulfonyl)piperidin-3-ol 
• 906360-16-5 1-mesyl piperidin-3-one 
• 906360-44-9 3-(4-methoxy-phenyl)-1-(toluene-4-sulfonyl)-piperidin-3-ol 
• 220384-68-9 1-(p-toluenesulfonyl)-piperidin-3-ol 
• 220384-55-4 1-(p-toluenesulfonyl)-piperidin-3-one 
• 626-55-1 3-Bromopyridine 
• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 40114-49-6 1-benzyl-3-piperidone 
• 946159-38-2 1-benzyl-3-(4-methoxyphenyl)piperidin-3-ol 

Downstream Products

• 81593-67-1 4-[3-(4-Methoxy-phenyl)-piperidin-1-yl]-4-oxo-butyric acid methyl ester 
• 344257-61-0 3-(4-methoxyphenyl)-1-propylpiperidine 
• 81593-71-7 4-[3-(4-Methoxy-phenyl)-piperidin-1-yl]-butan-1-ol 
• 81593-46-6 3,4-Dimethoxy-benzoic acid 4-[3-(4-methoxy-phenyl)-piperidin-1-yl]-butyl ester; compound with toluene-4-sulfonic acid 
• 79412-48-9 4-(1-Propyl-piperidin-3-yl)-phenol; hydrobromide 
• 1602923-17-0 (4-chlorophenyl)-carbamic acid (S)-2,2,2-trifluoro-1-[3-(4-methoxyphenyl)-piperidin-1-ylmethyl]-ethyl ester 
• 1602924-09-3 (2S)-1,1,1-trifluoro-3-(3-(4-methoxyphenyl)piperidin-1-yl)propan-2-ol 

Relevant articles and documents

Pd/C-catalyzed one-pot Suzuki-Miyaura cross-coupling/hydrogenation of pyridine derivatives

Using bromopyridines and methoxyphenyl boronic acid as starting materials, consecutive Suzuki-Miyaura cross-coupling and hydrogenation reactions were undertaken using a heterogeneous Pd/C catalyst in one-pot manner under mild conditions (balloon-pressure at room temperature for hydrogenation) with excellent yield. To counter Pd leaching as well as catalyst poisoning, addition of an appropriate amount of H2O was crucial to achieving successful AcOH-promoted hydrogenation, which ensured a selective reduction of the pyridine rings to the corresponding piperidines.

SUBSTITUTED METHYL PYRAZOLOPYRIMIDINONE AND METHYL IMIDAZOPYRAZINONE COMPOUNDS AS PDE1 INHIBITORS

A chemical entity of Formula (I) or Formula (II): wherein Ra, Rb, Re, and Rf have any of the values described herein, and compositions comprising such chemical entities; methods of making them; and their use in

B(C6F5)3-Catalyzed Cascade Reduction of Pyridines

B(C6F5)3 has been found to be an effective catalyst for reduction of pyridines and other electron-deficient N-heteroarenes with hydrosilanes (or hydroboranes) and amines as the reducing reagents. The success of this development hinges upon the realization of a cascade process of dearomative hydrosilylation (or hydroboration) and transfer hydrogenation. The broad functional-group tolerance (e.g. ketone, ester, unactivated olefins, nitro, nitrile, heterocycles, etc.) implies high practical utility.