344257-61-0

Basic information

• Product Name: Piperidine, 3-(4-methoxyphenyl)-1-propyl-
• CAS NO: 344257-61-0
• Molecular Formula: C15H23NO
• Molecular Weight: 233.354
• Mol File: 344257-61-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Piperidine, 3-(4-methoxyphenyl)-1-propyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Piperidine, 3-(4-methoxyphenyl)-1-propyl-(344257-61-0)
• EPA Substance Registry System: Piperidine, 3-(4-methoxyphenyl)-1-propyl-(344257-61-0)

Safety Data

• Hazardous Substances Data: 344257-61-0(Hazardous Substances Data)

Upstream product

• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 5958-02-1 3-(4-methoxyphenyl)pyridine 
• 19725-26-9 3-(4-methoxyphenyl)-piperidinehydrochloride 
• 626-55-1 3-Bromopyridine 
• 459453-63-5 3-(4-methoxyphenyl)-5-[(4-methylphenyl)sulfonyl]-1-propylpiperidine-2,6-dione 
• 459453-67-9 3-(4-methoxyphenyl)-5-[(4-methylphenyl)sulfonyl]-1-propyl-1,2,3,4-tetrahydropyridin-2-one 
• 101970-29-0 2-hydroxy-2-(4-methoxyphenyl)propionic acid methyl ester 
• 50415-68-4 methyl 2-(4-methoxyphenyl)prop-2-enoate 
• 100370-83-0 N-propyl-2-(4-methylphenyl)sulfonylacetamide 
• 13916-39-7 N-(propyl)chloroacetamide 
• 220384-55-4 1-(p-toluenesulfonyl)-piperidin-3-one 
• 220384-68-9 1-(p-toluenesulfonyl)-piperidin-3-ol 
• 906360-44-9 3-(4-methoxy-phenyl)-1-(toluene-4-sulfonyl)-piperidin-3-ol 
• 906360-23-4 3-(4-methoxyphenyl)-1-p-toluenesulfonylpiperidine 

Downstream Products

• 79412-48-9 4-(1-Propyl-piperidin-3-yl)-phenol; hydrobromide 

Relevant articles and documents

Concise synthesis of 3-arylpiperidines

We present an easy and straightforward synthesis of 3-arylpiperidines by Grignard addition of piperidin-3-one with different arylmagnesium bromide reagents and acidic dehydroxylation of the resulting tertiary alcohol with the combination of triethylsilane and boron trifluoride etherate. This facile strategy was further used to synthesize preclamol. A highly regioselective dehydration of 3-arylpiperidin-3-ol with boron trifluoride etherate was investigated for preparing 3-aryl-1,4,5,6-tetrahydropyridine skeleton. A novel selenium dioxide mediated dihydroperoxidation of 3-aryl-1,4,5,6-tetrahydropyridine was also examined.

3-Phenylpiperidines. Central Dopamine-Autoreceptor Stimulating Activity

Thirty compounds related to the selective dopamine-autoreceptor agonist 3-(3-hydroxyphenyl)-N-n-propylpiperidine have been synthesized and tested for central dopamine-autoreceptor stimulating activity.The 3-(3-hydroxyphenyl)piperidine moiety seems indispensable for high potency and selectivity.Introduction of an additional hydroxyl group into the 4-position of the aromatic ring gives a compound with dopaminergic activity but lacking selectivity for autoreceptors. 3-(3-Hydroxyphenyl)-N-n-propylpyrrolidine, 3-(3-hydroxy)-N-n-propylperhydroazepine, and 3-(3-hydroxyphenyl)quinuclidine were all inactive.The most potent compounds were the N-isopropyl-, N-n-butyl-, N-n-pentyl-, and N-phenethyl-substituted 3-(3-hydroxyphenyl)piperidine derivatives.None of the compounds investigated seemed to have central noradrenaline- or serotonin-receptor stimulating activity.