197979-64-9

Basic information

• Product Name: 2-[1-(3',5'-dimethoxyphenyl)-ethylidene]-3-[1-phenyl-(E)-methylidene]-succinic acid 1-methyl ester
• Synonyms: 2-[1-(3',5'-dimethoxyphenyl)-ethylidene]-3-[1-phenyl-(E)-methylidene]-succinic acid 1-methyl ester
• CAS NO: 197979-64-9
• Molecular Weight: 382.413
• Mol File: 197979-64-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-[1-(3',5'-dimethoxyphenyl)-ethylidene]-3-[1-phenyl-(E)-methylidene]-succinic acid 1-methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[1-(3',5'-dimethoxyphenyl)-ethylidene]-3-[1-phenyl-(E)-methylidene]-succinic acid 1-methyl ester(197979-64-9)
• EPA Substance Registry System: 2-[1-(3',5'-dimethoxyphenyl)-ethylidene]-3-[1-phenyl-(E)-methylidene]-succinic acid 1-methyl ester(197979-64-9)

Safety Data

• Hazardous Substances Data: 197979-64-9(Hazardous Substances Data)

Upstream product

• 39151-19-4 1-(3,5-dimethoxyphenyl)ethan-1-one 
• 65859-90-7 dimethyl (E)-benzylidenesuccinate 
• 197979-65-0 2-[1-(3',5'-dimethoxyphenyl)-(E)-ethylidene]-3-[1-phenyl-(E)-methylidene]-succinic acid 1-methyl ester 

Downstream Products

• 197979-67-2 methyl (Z)-3-(3',5'-dimethoxyphenyl)-2-[(E)-1-(4-methylpiperazin-1-ylcarbamoyl)-2-phenylvinyl]-2-butenoate hydrochloride 
• 1094172-77-6 C₂₄H₂₆O₇ 

Relevant articles and documents

Synthesis and evaluation of 1,4-diphenylbutadiene derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) production

Butadiene-imide 1 (T-686) derivatives were synthesized and evaluated for their inhibitory activity against PAI-1 production and their ADMET (DMPK and toxicology) profiles. Among these derivatives, compound 15k (T-2639) showed good antithrombotic activity in two rat thrombosis models without affecting bleeding time, indicating reduction of haemorrhagic risk. We also describe in this report a practical synthesis of 15k suitable for scale-up using Z,E-selective Stobbe condensation.