198281-55-9 Usage
Description
3-(4-METHYL-PIPERAZIN-1-YLMETHYL)-ANILINE is an organic compound that serves as a key intermediate in the synthesis of various chemical compounds, particularly those with potential pharmaceutical applications. It is characterized by its unique molecular structure, which features a piperazine ring and an aniline group, allowing it to form important bonds and interactions with other molecules.
Uses
Used in Pharmaceutical Industry:
3-(4-METHYL-PIPERAZIN-1-YLMETHYL)-ANILINE is used as a chemical intermediate for the preparation of pyrido[3,4-d]pyrimidin-4-ol derivatives. These derivatives have been identified as histone demethylase inhibitors, which play a crucial role in the regulation of gene expression and have potential applications in the treatment of various diseases, including cancer.
Used in the Synthesis of Histone Demethylase Inhibitors:
3-(4-METHYL-PIPERAZIN-1-YLMETHYL)-ANILINE is used as a building block in the development of novel histone demethylase inhibitors. These inhibitors can modulate the activity of histone demethylases, which are enzymes that remove methyl groups from histone proteins, thereby affecting gene expression. By targeting these enzymes, histone demethylase inhibitors may offer therapeutic benefits in the treatment of diseases with aberrant epigenetic regulation, such as cancer.
Check Digit Verification of cas no
The CAS Registry Mumber 198281-55-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,8,2,8 and 1 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 198281-55:
(8*1)+(7*9)+(6*8)+(5*2)+(4*8)+(3*1)+(2*5)+(1*5)=179
179 % 10 = 9
So 198281-55-9 is a valid CAS Registry Number.
198281-55-9Relevant articles and documents
Methylpyrazole derivatives as RET inhibitor
-
Paragraph 0633-0635; 0639-0642, (2021/07/21)
The invention relates to a methylpyrazole derivative as an RET inhibitor, in particular to a compound as shown in a formula (I), a stereoisomer and pharmaceutically acceptable salt thereof, a preparation method and a pharmaceutical composition thereof. The compound of the formula (I) can be used for preventing or treating diseases mediated by abnormal RET activity.
2, 4 -DIAMINOPYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS
-
Page/Page column 139-140, (2012/05/20)
The present invention relates to novel pyrimide derivatives of formula (I): that are useful as kinase inhibitors. More particularly, the present invention relates to novel pyrimidine compounds, methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment of proliferative disorders.
Aminomethylation via cyclopalladated-ferrocenylimine-complexes-catalyzed Suzuki-Miyaura coupling of aryl halides with potassium N, N - dialkylaminomethyltrifluoroborates
Zou, Dapeng,Cui, Hongmeng,Qin, Lijin,Li, Jingya,Wu, Yangjie,Wu, Yusheng
scheme or table, p. 349 - 356 (2011/03/23)
Using cyclopalladated ferrocenylimine complexes (1-3 mol%) as catalysts, the Suzuki-Miyaura coupling of potassium N,N-dialkylaminomethyltrifluoroborates with aryl and heteroaryl halides were carried out in a 10:1 THF-H2O mixture at 80° in the presence of Cs2CO3 (3.0 equiv) as base, giving the desired cross-coupling products in 14-87% yields. A variety of potassium alkyltrifluoroborates were also examined. Georg Thieme Verlag Stuttgart New York.