943189-22-8

Basic information

• Product Name: N-methyl-N'-[3-(4-methylpiperazin-1-ylmethyl)phenyl]pyrimidine-4,6-diamine
• Synonyms: N-methyl-N'-[3-(4-methylpiperazin-1-ylmethyl)phenyl]pyrimidine-4,6-diamine
• CAS NO: 943189-22-8
• Molecular Weight: 312.418
• Mol File: 943189-22-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-methyl-N'-[3-(4-methylpiperazin-1-ylmethyl)phenyl]pyrimidine-4,6-diamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-methyl-N'-[3-(4-methylpiperazin-1-ylmethyl)phenyl]pyrimidine-4,6-diamine(943189-22-8)
• EPA Substance Registry System: N-methyl-N'-[3-(4-methylpiperazin-1-ylmethyl)phenyl]pyrimidine-4,6-diamine(943189-22-8)

Safety Data

• Hazardous Substances Data: 943189-22-8(Hazardous Substances Data)

Upstream product

• 619-23-8 3-Nitrobenzyl chloride 
• 198281-54-8 1-methyl-4-(3-nitro-benzyl)-piperazine 
• 109-01-3 1-methyl-piperazine 
• 65766-32-7 6-chloro-N-methylpyrimidin-4-amine 
• 198281-55-9 3-(4-methyl-piperazin-1-ylmethyl)-phenylamine 

Relevant articles and documents

Discovery of 3-(2,6-Dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl- piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), A potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinase

A novel series of N-aryl-N′-pyrimidin-4-yl ureas has been optimized to afford potent and selective inhibitors of the fibroblast growth factor receptor tyrosine kinases 1, 2, and 3 by rationally designing the substitution pattern of the aryl ring. On the b