198560-10-0

Basic information

• Product Name: FMOC-HOMO-L-TYROSINE
• Synonyms: (S)-N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-2-AMINO-4-HYDROXYBENZENEBUTANOIC ACID;(S)-2-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-4-(4-HYDROXY-PHENYL)-BUTYRIC ACID;N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-HOMO-TYROSINE;FMOC-TYR(NOCH2)-OH;FMOC-HOMOTYR-OH;FMOC-HOMO-TYROSINE;FMOC-HOMO-L-TYROSINE;FMOC-HTY-OH
• CAS NO: 198560-10-0
• Molecular Formula: C₂₅H₂₃NO₅
• Molecular Weight: 417.45
• Product Categories: Amino Acids
• Mol File: 198560-10-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 678.8°C at 760 mmHg
• Flash Point: 364.3°C
• Appearance: /
• Density: 1.311g/cm³
• Vapor Pressure: 2.35E-19mmHg at 25°C
• Refractive Index: 1.641
• Storage Temp.: Store at 0°C
• PKA: 3.87±0.10(Predicted)
• CAS DataBase Reference: FMOC-HOMO-L-TYROSINE(CAS DataBase Reference)
• NIST Chemistry Reference: FMOC-HOMO-L-TYROSINE(198560-10-0)
• EPA Substance Registry System: FMOC-HOMO-L-TYROSINE(198560-10-0)

Safety Data

• Hazardous Substances Data: 198560-10-0(Hazardous Substances Data)

Usage

Chemical Properties

White powder

InChI:InChI=1/C25H23NO5/c27-17-12-9-16(10-13-17)11-14-23(24(28)29)26-25(30)31-15-22-20-7-3-1-5-18(20)19-6-2-4-8-21(19)22/h1-10,12-13,22-23,27H,11,14-15H2,(H,26,30)(H,28,29)/t23-/m0/s1

Upstream product

• 28920-43-6 (fluorenylmethoxy)carbonyl chloride 
• 141899-12-9 L-homotyrosine hydrobromide 
• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 
• 221243-01-2 (S)-homotyrosine 
• 766-51-8 2-Chloroanisole 
• 642408-92-2 (S)-4-(3-Chloro-4-methoxy-phenyl)-2-(3-methyl-ureido)-4-oxo-butyric acid 

Downstream Products

• 642408-91-1 2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-(4-hydroxy-3-nitro-phenyl)-butyric acid 
• 1002721-43-8 C₃₂H₃₃NO₁₀ 
• 551929-85-2 (2S,4S)-4-Azido-1-{(2S,3R)-2-[(S)-4-[3-(2-benzyloxycarbonylamino-acetylamino)-4-hydroxy-phenyl]-2-(9H-fluoren-9-ylmethoxycarbonylamino)-butyrylamino]-3-hydroxy-butyryl}-pyrrolidine-2-carboxylic acid methyl ester 
• 551929-86-3 [26-azido-6-{2-[3-(2-benzyloxycarbonylamino-acetylamino)-4-hydroxy-phenyl]-ethyl}-11-hydroxy-3,15-bis-(1-hydroxy-ethyl)-2,5,8,14,17,23-hexaoxo-1,4,7,13,16,22-hexaaza-tricyclo[22.3.0.0^9,13]heptacos-18-yl]-carbamic acid tert-butyl ester 
• 296774-19-1 hTyr(Ot-Bu)Ot-Bu 
• 296774-20-4 FmocHyp(Ot-Bu)hTyr(Ot-Bu)Ot-Bu 
• 296774-47-5 Fmoc-homotyrosine 4'-allyloxyphenylmethyl ether trimethylsilylethyl ester 
• 296774-21-5 FmocThr(Ot-Bu)-Hyp(Ot-Bu)-hTyr(Ot-Bu)Ot-Bu 

Relevant articles and documents

Discovery, SAR, synthesis, pharmacokinetic and biochemical characterization of A-192411: A novel fungicidal lipopeptide-(I)

The echinocandin class of cyclic lipopepetides has been simplified to discover potent antifungal compounds. Namely A-192411 shows good in vitro activity against common pathogenic yeasts and has an acceptable safety window in vivo. Discovery, limited SAR, synthesis, biochemical and pharmaco-dynamic profiles of A-192411 are presented.