198757-93-6

Basic information

• Product Name: Butanamide, N-[2,5-dimethoxy-3-[(phenylsulfonyl)methyl]phenyl]-4-[[(1,1-dimethylethyl )dimethylsilyl]oxy]-3-methoxy-, (3R)-
• CAS NO: 198757-93-6
• Molecular Formula: C26H39NO7SSi
• Molecular Weight: 537.75
• Mol File: 198757-93-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Butanamide, N-[2,5-dimethoxy-3-[(phenylsulfonyl)methyl]phenyl]-4-[[(1,1-dimethylethyl )dimethylsilyl]oxy]-3-methoxy-, (3R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Butanamide, N-[2,5-dimethoxy-3-[(phenylsulfonyl)methyl]phenyl]-4-[[(1,1-dimethylethyl )dimethylsilyl]oxy]-3-methoxy-, (3R)-(198757-93-6)
• EPA Substance Registry System: Butanamide, N-[2,5-dimethoxy-3-[(phenylsulfonyl)methyl]phenyl]-4-[[(1,1-dimethylethyl )dimethylsilyl]oxy]-3-methoxy-, (3R)-(198757-93-6)

Safety Data

• Hazardous Substances Data: 198757-93-6(Hazardous Substances Data)

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 198758-09-7 (R)-N-(3-Benzenesulfonylmethyl-2,5-dimethoxy-phenyl)-4-hydroxy-3-methoxy-butyramide 
• 198758-08-6 2,5-dimethoxy-3-nitro-1-[(phenylsulfonyl)methyl]benzene 
• 198757-96-9 2,5-dimethoxy-3-[(phenylsulfonyl)methyl]aniline 
• 198758-07-5 1-(bromomethyl)-2,5-dimethoxy-3-nitrobenzene 
• 198758-06-4 (2,5-dimethoxy-3-nitrophenyl)methanol 
• 137008-54-9 (R)-4-Methoxy-dihydro-furan-2-one 
• 74422-90-5 2,5-dimethoxy-3-nitrobenzaldehyde 
• 669065-48-9 (R)-4-(tert-butyldimethylsilyloxy)-3-hydroxy-butyric acid benzyl ester 
• 669065-40-1 (R)-4-(tert-butyldimethylsilyloxy)-3-methoxy-butyric acid benzyl ester 
• 669065-49-0 (R)-4-(tert-butyldimethylsilyloxy)-3-methoxy-butyric acid 
• 196302-51-9 (3-Bromo-2,5-dimethoxy-phenyl)-methanol 
• 669065-39-8 1-bromo-3-bromomethyl-2,5-dimethoxymethylbenzene 
• 68216-65-9 3-bromo-2,5-dimethoxybenzaldehyde 

Downstream Products

• 198758-10-0 (R)-N-{3-[(Z)-(5R,6S,7S)-1-Benzenesulfonyl-5-(tert-butyl-dimethyl-silanyloxy)-9,9-dimethoxy-4,6-dimethyl-7-triisopropylsilanyloxy-non-3-enyl]-2,5-dimethoxy-phenyl}-4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-butyramide 
• 198758-12-2 (R)-1-{3-[(Z)-(5R,6S,7S)-5-(tert-Butyl-dimethyl-silanyloxy)-9,9-dimethoxy-4,6-dimethyl-7-triisopropylsilanyloxy-non-3-enyl]-2,5-dimethoxy-phenyl}-5-hydroxy-4-methoxy-pyrrolidin-2-one 
• 198757-97-0 (R)-4-(tert-Butyl-dimethyl-silanyloxy)-N-{3-[(Z)-(5R,6S,7S)-5-(tert-butyl-dimethyl-silanyloxy)-9,9-dimethoxy-4,6-dimethyl-7-triisopropylsilanyloxy-non-3-enyl]-2,5-dimethoxy-phenyl}-3-methoxy-butyramide 
• 198758-00-8 (R)-2-(Cyclohexanecarbonyl-amino)-propionic acid (6E,8E,10E,16Z)-(5R,13S,14S,15R)-15-(tert-butyl-dimethyl-silanyloxy)-5,22,24-trimethoxy-14,16-dimethyl-3-oxo-2-aza-bicyclo[18.3.1]tetracosa-1⁽²³⁾,6,8,10,16,20⁽²⁴⁾,21-heptaen-13-yl ester 
• 198758-11-1 (R)-N-{3-[(Z)-(5R,6S,7S)-5-(tert-Butyl-dimethyl-silanyloxy)-9,9-dimethoxy-4,6-dimethyl-7-triisopropylsilanyloxy-non-3-enyl]-2,5-dimethoxy-phenyl}-4-hydroxy-3-methoxy-butyramide 
• 198757-98-1 (E)-(R)-5-Iodo-3-methoxy-pent-4-enoic acid {3-[(3Z,9E)-(5R,6S,7S)-5-(tert-butyl-dimethyl-silanyloxy)-10-iodo-4,6-dimethyl-7-triisopropylsilanyloxy-deca-3,9-dienyl]-2,5-dimethoxy-phenyl}-amide 
• 82189-03-5 (+)-mycotrienin I 
• 81904-15-6 (+)-mycotrienol I 
• 669065-54-7 [1(3Z,5R,6S,7S),3R]-N-{3-[7,9-bis(tert-butyl-dimethylsilyloxy)-4,6-dimethyl-5-triisopropylsilyloxy-non-3-enyl]-2,5-dimethoxy-phenyl}-4-(tert-butyldimethylsilyloxy)-3-methoxy-N-(2,2,2-trichloroethoxymethyl)-butyramide 
• 669065-44-5 [1(3Z,5R,6S,7S),3R]-N-{3-[7,9-bis(tert-butyl-dimethylsilyloxy)-4,6-dimethyl-5-triisopropylsilyloxy-non-3-enyl]-2,5-dimethoxy-phenyl}-4-(tert-butyldimethylsilyloxy)-3-methoxy-butyramide 
• 669065-55-8 [1(3Z,5R,6S,7S),3R]-N-{3-[7-(tert-butyl-dimethylsilyloxy)-9-hydroxy-4,6-dimethyl-5-triisopropylsilyloxy-non-3-enyl]-2,5-dimethoxy-phenyl}-4-hydroxy-3-methoxy-N-(2,2,2-trichloroethoxymethyl)-butyramide 
• 669065-45-6 [1(3Z,5R,6S,7S),3R]-N-{3-[7-(tert-butyl-dimethylsilyloxy)-9-oxo-4,6-dimethyl-5-triisopropylsilyloxy-non-3-enyl]-2,5-dimethoxy-phenyl}-3-methoxy-4-oxo-N-(2,2,2-trichloroethoxymethyl)-butyramide 
• 669065-35-4 [1(3Z,5R,6S,7S,9E),3R,4E]-3-methoxy-hepta-4,6-dienoic acid {3-[7-(tert-butyl-dimethylsilyloxy)-4,6-dimethyl-5-triisopropylsilyloxy-dodeca-3,9,11-trienyl]-2,5-dimethoxy-phenyl}-amide 
• 669065-53-6 [1(1RS,3Z,5R,6S,7S),3R]-N-{3-[1-benzenesulfonyl-7,9-bis(tert-butyl-dimethylsilyloxy)-4,6-dimethyl-5-triisopropylsilyloxy-non-3-enyl]-2,5-dimethoxy-phenyl}-4-(tert-butyldimethylsilyloxy)-3-methoxy-butyramide 

Relevant articles and documents

A Convergent Synthesis of the Macrocyclic Core of Cytotrienins: Application of RCM for Macrocyclization

(Equation presented) The asymmetric synthesis of the fully elaborated macrocyclic core of cytotrienins A-D, potent apoptosis-inducing agents, is described. Synthetic highlights include the construction of the aniline bond using a copper-mediated amidation and the use of a ring-closing metathesis (RCM) reaction to efficiently install the (E,E,E)-triene and simultaneously construct the macrocyclic lactam.

Total synthesis of (+)-mycotrienol and (+)-mycotrienin I

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