198836-40-7

Basic information

• Product Name: N-benzyl-N-(2-nitrophenylsulfonyl)-L-valine methyl ester
• Synonyms: N-benzyl-N-(2-nitrophenylsulfonyl)-L-valine methyl ester
• CAS NO: 198836-40-7
• Molecular Weight: 406.459
• Mol File: 198836-40-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-benzyl-N-(2-nitrophenylsulfonyl)-L-valine methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyl-N-(2-nitrophenylsulfonyl)-L-valine methyl ester(198836-40-7)
• EPA Substance Registry System: N-benzyl-N-(2-nitrophenylsulfonyl)-L-valine methyl ester(198836-40-7)

Safety Data

• Hazardous Substances Data: 198836-40-7(Hazardous Substances Data)

Upstream product

• 6306-52-1 L-valine methylester hydrochloride 
• 1694-92-4 2-Nitrobenzenesulfonyl chloride 
• 100-39-0 benzyl bromide 
• 198836-33-8 methyl (S)-3-methyl-2-(2-nitrophenylsulfonamido)butanoate 

Downstream Products

• 40216-62-4 N-benzyl-L-valine methyl ester 

Relevant articles and documents

A facile rearrangement of N-alkyl, N-(0 or p-nitrophenylsulfonamide)- α-amino esters

The N-alkylation of primary nitrophenylsulfonamides followed by removal of the nitrophenylsulfonamide moiety under nucleophilic conditions to provide secondary amines has become an established literature procedure. Application of this methodology with les

A facile method for the N-alkylated of α-amino esters

Monoalkylation of the α-amino group of α-amino acid derivatives can be facilitated using 2 -and 4-nitrophenylsulfonamide intermediates. The nitrophenylsulfonamides of α-amino esters can be alkylated using an equimolar amount of carbonate base and a variety of alkyl bromides. Ready removal of the nitrophenylsulfonyl group is facilitated by S(N)Ar reaction between the N-alkylated sulfonamide and phenylthiolate to give the N-alkylated α-amino esters in good yield without racemisation of the chiral α-centres.