40216-62-4

Basic information

• Product Name: L-Valine, N-(phenylmethyl)-, methyl ester
• CAS NO: 40216-62-4
• Molecular Formula: C13H19NO2
• Molecular Weight: 221.299
• Mol File: 40216-62-4.mol
• Article Data: 26

Chemical Properties

• CAS DataBase Reference: L-Valine, N-(phenylmethyl)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Valine, N-(phenylmethyl)-, methyl ester(40216-62-4)
• EPA Substance Registry System: L-Valine, N-(phenylmethyl)-, methyl ester(40216-62-4)

Safety Data

• Hazardous Substances Data: 40216-62-4(Hazardous Substances Data)

Upstream product

• 4070-48-8 L-valine methyl ester 
• 100-52-7 benzaldehyde 
• 69367-52-8 methyl 2-bromo-3-methylbutanoic ester 
• 100-46-9 benzylamine 
• 13803-83-3 methyl 2-(benzylideneamino)-3-methylbutanoate 
• 4070-48-8 L-Valine methyl ester 
• 100-39-0 benzyl bromide 
• 6306-52-1 L-valine methylester hydrochloride 
• 13803-83-3 methyl (S)-2-(benzylideneamino)-3-methylbutanoate 
• 198836-40-7 N-benzyl-N-(2-nitrophenylsulfonyl)-L-valine methyl ester 
• 106-95-6 allyl bromide 
• 3952-67-8 methyl 3-methyl-2-ketobutanoate 
• 72-18-4 L-valine 
• 198836-33-8 methyl (S)-3-methyl-2-(2-nitrophenylsulfonamido)butanoate 

Downstream Products

• 452282-29-0 C₁₃H₁₈N₂O₃ 
• 433735-02-5 (S)-N-benzyl-N-chloroacetylvaline methyl ester 
• 900187-89-5 (S)-methyl N-benzyl-N-(tert-butoxycarbonyl)valinate 
• 118460-23-4 (S)-methyl 2-(benzyl(methyl)amino)-3-methylbutanoate 
• 5619-05-6 DL-valine methyl ester hydrochloride 
• 1403983-89-0 2-[benzyl(methyl)amino]-3-methyl-1,1-diphenylbutan-1-ol 
• 1052703-92-0 C₁₈H₂₅NO₅ 
• 912998-94-8 2-[benzyl(4-fluorobenzoyl)amino]-3-methylbutanoic acid 
• 129156-92-9 N-benzyl-N-[(1S)-1-(methoxymethyl)-2-methylpropyl]amine 

Relevant articles and documents

Electroreductive intramolecular coupling of chiral α-imino esters: Stereoselective synthesis of mixed ketals of cis-2,4-disubstituted azetidine-3-ones

The electroreduction of chiral aromatic α-imino esters prepared from (S)-α-amino acids, such as (S)-valine, (S)-leucine, and (S)-phenylalanine, in the presence of chlorotrimethylsilane and triethylamine afforded four-membered cyclized products, mixed ketals of cis-2,4-disubstituted azetidine-3-ones, stereospecifically (>99% de, 85-99% ee). The best result of the electroreductive cyclization was obtained using Bu4NClO 4 as a supporting electrolyte and a Pt cathode. The absolute stereochemistry of the obtained single stereoisomers was confirmed to be 2R,3R,4S by X-ray crystallography. Calculations for the transition states of the cyclization support the stereospecific formation of the (2R,3R,4S)-isomers.

ANTIVIRAL COMPOUNDS

The present invention relates to novel compounds of general formula (I) wherein the groups X, and R1 to R4 have the meanings given in the description and claims, process for preparing these compounds and their use as for treating, preventing or ameliorating viral infections and their use for treating, preventing or ameliorating diseases which are associated with PLA2G16.

(η5-Pentamethylcyclopentadienyl)iridium Complex Catalyzed Imine Reductions Utilizing the Biomimetic 1,4-NAD(P)H Cofactor and N-Benzyl-1,4-dihydronicotinamide as the Hydride-Transfer Agent

The interaction between synthetic organometallic complexes and metabolic cofactors has proven to be a newly emerging topic in bioorganometallic chemistry. Thus, the first cationic Cp*Ir-catalyzed (Cp=η5-pentamethylcyclopentadienyl) imine reduction in neutral buffered aqueous medium was examined. The reaction was found to proceed through hydride transfer from NADH as the hydride source at room temperature in air. Cationic Cp*Ir complexes proved to be the most efficient catalysts for this transformation. We also highlighted that the choice of the proton source was essential. The method was subsequently applied to cyclic and noncyclic imines. Eventually, the concept was extended to the reductive alkylation of one amine.