13803-83-3

Basic information

• Product Name: Valine, N-(phenylmethylene)-, methyl ester
• CAS NO: 13803-83-3
• Molecular Formula: C13H17NO2
• Molecular Weight: 219.283
• Mol File: 13803-83-3.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: Valine, N-(phenylmethylene)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Valine, N-(phenylmethylene)-, methyl ester(13803-83-3)
• EPA Substance Registry System: Valine, N-(phenylmethylene)-, methyl ester(13803-83-3)

Safety Data

• Hazardous Substances Data: 13803-83-3(Hazardous Substances Data)

Upstream product

• 5619-05-6 DL-valine methyl ester hydrochloride 
• 100-52-7 benzaldehyde 
• 640-68-6 D-Val-OH 
• 16118-22-2 benzylidenamine 
• 72-18-4 L-valine 
• 27593-61-9 methyl N-phenylmethylenecarbamate 
• 17599-61-0 N-benzylidene-1,1,1-trimethylsilanamine 
• 6306-52-1 L-valine methylester hydrochloride 
• 4070-48-8 L-Valine methyl ester 
• 134920-16-4 N-methoxycarbonyl-3-phenyloxaziridine 
• 4070-48-8 L-valine methyl ester 

Downstream Products

• 40216-62-4 N-benzyl-L-valine methyl ester 
• 4070-48-8 D-Valine methyl ester 
• 132599-68-9 N-<(S)-1-(methoxycarbonyl)-2-methylpropyl>-(6R)-2,3-didehydro-6-phenylpiperidin-4-one 
• 132599-69-0 N-<(S)-1-(methoxycarbonyl)-2-methylpropyl>-(6S)-2,3-didehydro-6-phenylpiperidin-4-one 
• 130517-98-5 methyl N-[(4S)-4-phenylbut-1-en-4-yl]-(S)-valinate 
• 313344-25-1 2-[4-(benzyloxy)phenylmethyl]furan 
• 1266386-64-4 trimethyl 2-isopropyl-5-phenyl-2H-pyrrole-2,3,4-tricarboxylate 
• 4383-23-7 (S)-1-phenylbut-3-en-1-amine 
• 76715-91-8 2-((3S,4R)-3-Acetylamino-2-oxo-4-phenyl-azetidin-1-yl)-3-methyl-butyric acid methyl ester 
• 98241-47-5 Ac-Phe-Val-OMe 
• 76715-99-6 2-(2-Hydroxy-3-phenyl-propionylamino)-3-methyl-butyric acid methyl ester 
• 112674-78-9 3-Methyl-2-[(R)-2-((R)-2-oxo-4-phenyl-oxazolidin-3-yl)-3-phenyl-propionylamino]-butyric acid 
• 112674-81-4 Phe-Val 
• 75984-55-3 dimethyl 2-isopropyl-c-5-phenyl-r-2-t-4-pyrrolidinedicarboxylate 

Relevant articles and documents

Utilization of fluoroform for difluoromethylation in continuous flow: A concise synthesis of α-difluoromethyl-amino acids

Fluoroform (CHF3) can be considered as an ideal reagent for difluoromethylation reactions. However, due to the low reactivity of fluoroform, only very few applications have been reported so far. Herein we report a continuous flow difluoromethyl

Method for preparing amino ether compounds

The invention belongs to the technical field of organic synthesis and relates to a method for preparing amino ether compounds. The method comprises the following steps: by taking amino alcohol as a raw material, protecting amino in the amino alcohol so as to obtain Schiff base; carrying out an etherification reaction on the hydroxyl group in the Schiff base; and finally, performing amino deprotection, thereby obtaining corresponding amino ethers. The method disclosed by the invention has high regio-selectivity, the substrates of higher than 99.9% are subjected to etherification reaction, the reaction conversion ratio of each step is higher than 99.8%, and the total yield is higher than 95%; when amino alcohol is chiral, the amino ethers with retention of configuration can be obtained; and moreover, each step of the method is a conventional operation, the process cost is low, and three wastes are few, the energy consumption is low, an environment-friendly effect is achieved, and large-scale industrial production is easily realized.

A convenient method for the enantiomeric separation of α-amino acid esters as benzophenone imine schiff base derivatives

A convenient liquid chromatographic method for the separation of α-amino acid esters as benzophenone Schiff base derivatives on coated chiral stationary phases (CSPs) (Chiralcel OD-H, Chiralcel OD, Chiralpak AD-H, Chiralpak AD, and Chiralpak AS) or covalently immobilized CSPs (Chiralpak IA, Chiralpak IB, and Chiralpak IC) derived from polysaccharide derivatives is described. Benzophenone imine derivatives of α-amino acid esters were readily prepared by stirring benzophenone imine and the hydrochloride salts of α-amino acid esters in 2-propanol. The chromatographic separations were conducted at a flow rate 1.0 mL/min and a detection wavelength of 254 nm; 0.5% 2-propanol/hexane (v/v) was used on CSPs. In general, the resolution of Chiralpak IC was superior to those of the other CSPs. In addition, the resolutions of other arylimine derivatives of α-amino acid esters and the effects of different mobile phases on the enantiomeric separation of α-amino acid esters as benzophenone imine derivatives on Chiralpak IC were investigated.