1991-87-3

Basic information

• Product Name: 4-Methylphenyl-L-alanine
• Synonyms: (S)-2-AMINO-3-(4-METHYLPHENYL)PROPANOIC ACID;(S)-2-AMINO-3-P-TOLYL-PROPIONIC ACID;RARECHEM BK PT 0067;L-4-METHYLPHE;L-4-METHYLPHENYLALANINE;H-PHE(4-ME)-OH;H-P-ME-PHENYLALANINE;H-P-ME-PHE-OH
• CAS NO: 1991-87-3
• Molecular Formula: C₁₀H₁₃NO₂
• Molecular Weight: 179.22
• Product Categories: Amino Acids;Phenylalanine analogs and other aromatic alpha amino acids;Phenylalanine [Phe, F];Unusual Amino Acids;Amino acids methyl、ethyl、t-butyl series;a-amino
• Mol File: 1991-87-3.mol
• Article Data: 15

Chemical Properties

• Melting Point: 271 °C(dec.)
• Boiling Point: 323.5 °C at 760 mmHg
• Flash Point: 149.5 °C
• Appearance: /
• Density: 1.165 g/cm³
• Vapor Pressure: 0.000107mmHg at 25°C
• Refractive Index: 1.568
• Storage Temp.: Store at RT.
• Solubility: Sparingly soluble (0.014 g/L) (25°C).
• PKA: 2.23±0.10(Predicted)
• CAS DataBase Reference: 4-Methylphenyl-L-alanine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methylphenyl-L-alanine(1991-87-3)
• EPA Substance Registry System: 4-Methylphenyl-L-alanine(1991-87-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-28
• Hazardous Substances Data: 1991-87-3(Hazardous Substances Data)

Usage

Description

4-Methylphenyl-L-alanine, also known as 4-Methyl-L-phenylalanine, is a white to off-white powder with unique chemical properties. It is an amino acid derivative that plays a significant role in various industrial applications due to its ability to maintain pH levels and remove acid components from gases.

Uses

Used in Absorption Liquids:
4-Methylphenyl-L-alanine is used as an absorption liquid for removing acid components such as carbon dioxide and hydrogen sulfide from gases. Its effectiveness in capturing these harmful components makes it a valuable asset in the purification of gases and air quality management.
Used in Buffer Solutions:
In the field of chemistry and biology, 4-Methylphenyl-L-alanine is used as a buffering agent to maintain the pH of aqueous liquids at a constant level. This property is crucial for various laboratory procedures and industrial processes that require stable pH conditions for optimal results.
Used in Pharmaceutical Industry:
4-Methylphenyl-L-alanine is also utilized in the pharmaceutical industry for its potential therapeutic applications. Its ability to interact with biopolymers and macromolecules makes it a promising candidate for the development of new drugs and therapies.
Used in Food Industry:
In the food industry, 4-Methylphenyl-L-alanine may be employed as an additive to enhance the taste, texture, or shelf life of certain products. Its specific applications may vary depending on the requirements of the industry and the desired outcomes.
Used in Cosmetics Industry:
4-Methylphenyl-L-alanine can be used in the cosmetics industry for its potential benefits in skincare and personal care products. Its ability to interact with proteins and other molecules may contribute to the development of innovative formulations that address various skin concerns.

InChI:InChI=1/C10H13NO2/c1-7-2-4-8(5-3-7)6-9(11)10(12)13/h2-5,9H,6,11H2,1H3,(H,12,13)/t9-/m1/s1

Upstream product

• 49759-58-2 (S)-2-Benzyloxycarbonylamino-3-p-tolyl-propionic acid 
• 6955-13-1 N-acetyl-4-methyl-phenylalanine 
• 74046-14-3 (S)-2-Acetylamino-3-p-tolyl-propionic acid 
• 207910-81-4 3-(4-methylphenyl)-2-oxopropanoic acid 
• 93634-54-9 (Z)-2-methyl-4-(4-methylbenzylidene)oxazol-5(4H)-one 
• 104-87-0 4-methyl-benzaldehyde 
• 104-81-4 4-Methylbenzyl bromide 
• 49864-40-6 2-Benzyloxycarbonylamino-2-(4-methyl-benzyl)-malonic acid monoethyl ester 
• 49759-54-8 2-Benzyloxycarbonylamino-3-p-tolyl-propionic acid ethyl ester 
• 49759-46-8 2-Benzyloxycarbonylamino-2-(4-methyl-benzyl)-malonic acid diethyl ester 
• 4599-47-7 p-methylphenylalanine 
• 1866-39-3 trans-p-methylcinnamic acid 
• 683809-83-8 2-amino-3-(4-fluoromethylphenyl)propionic acid 
• 1866-39-3 4-methylcinnamic acid 

Downstream Products

• 82057-63-4 (S)-2-(2-Nitro-phenylsulfanylamino)-3-p-tolyl-propionic acid 
• 74046-14-3 (S)-2-Acetylamino-3-p-tolyl-propionic acid 
• 17028-03-4 3-(4-hydroxy-3-methylphenyl)-L-alanine 
• 15742-88-8 L-(p-hydroxymethyl)phenylalanine 
• 479064-87-4 (R)-3-amino-3-(4-methyl-phenyl)-propionic acid 
• 82057-57-6 o-nitrobenzenesulfenyl-p-methylphenylalanyl-isoleucyl-glutaminyl-asparaginyl-S-(β-carboxyethyl)homocysteinyl-prolyl-leucyl-glycine amide 
• 4599-47-7 p-methylphenylalanine 
• 1866-39-3 trans-p-methylcinnamic acid 
• 39260-86-1 p-Methylphenethylamine hydrochloride 
• 98698-22-7 (S)-7-methyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid 
• 204260-38-8 (2S)-2-(9H-fluorene-9-ylmethoxycarbonylamino)-3-(4-methylphenyl)propanoic acid 

Relevant articles and documents

A novel phenylalanine ammonia-lyase from Pseudozyma antarctica for stereoselective biotransformations of unnatural amino acids

A novel phenylalanine ammonia-lyase of the psychrophilic yeast Pseudozyma antarctica (PzaPAL) was identified by screening microbial genomes against known PAL sequences. PzaPAL has a significantly different substrate binding pocket with an extended loop (26 aa long) connected to the aromatic ring binding region of the active site as compared to the known PALs from eukaryotes. The general properties of recombinant PzaPAL expressed in E. coli were characterized including kinetic features of this novel PAL with L-phenylalanine (S)-1a and further racemic substituted phenylalanines rac-1b-g,k. In most cases, PzaPAL revealed significantly higher turnover numbers than the PAL from Petroselinum crispum (PcPAL). Finally, the biocatalytic performance of PzaPAL and PcPAL was compared in the kinetic resolutions of racemic phenylalanine derivatives (rac-1a-s) by enzymatic ammonia elimination and also in the enantiotope selective ammonia addition reactions to cinnamic acid derivatives (2a-s). The enantiotope selectivity of PzaPAL with o-, m-, p-fluoro-, o-, p-chloro- and o-, m-bromo-substituted cinnamic acids proved to be higher than that of PcPAL.

Ligand-Enabled β-C–H Arylation of α-Amino Acids Without Installing Exogenous Directing Groups

Herein we report acid-directed β-C(sp3)-H arylation of α-amino acids enabled by pyridine-type ligands. This reaction does not require the installation of an exogenous directing group, is scalable, and enables the preparation of Fmoc-protected unnatural amino acids in three steps. The pyridine-type ligands are crucial for the development of this new C(sp3)-H arylation.

A new type of chiral-pyridoxamines for catalytic asymmetric transamination of α-keto acids

A new type of chiral pyridoxamines bearing an adjacent chiral stereocenter has been developed via multi-step synthesis. The pyridoxamines displayed catalytic activity in asymmetric transamination of α-keto acids to give a variety of optically active amino acids in 27–78% yields with 34–62% ee's under very mild conditions. This work provides a synthetic strategy to construct new chiral pyridoxamines using bromopyridine 7 as a key synthon and also represents an early example of the applications of chiral pyridoxamines in asymmetric catalysis.