2000-66-0 Usage
Description
(17α)-Pregn-4-ene-3,20-dione, also known as 17α-Progesterone, is a steroid hormone derived from cholesterol. It serves as a precursor to testosterone and plays a crucial role in the biosynthesis of other sex hormones. (17α)-Pregn-4-ene-3,20-dione has a molecular structure characterized by its four fused rings and a ketone group at the 3-position, along with a double bond at the 4-position.
Uses
Used in Pharmaceutical Industry:
(17α)-Pregn-4-ene-3,20-dione is used as a hormone precursor for the synthesis of testosterone and other sex hormones, which are essential for various physiological functions in the human body. It is particularly important for the development and regulation of the reproductive system.
Used in Diagnostic Applications:
(17α)-Pregn-4-ene-3,20-dione is used as a diagnostic agent in the identification and study of ovarian Leydig cell tumor disease. This condition is characterized by the presence of abnormal cells in the ovaries, and the hormone can help in the detection and monitoring of the disease.
Check Digit Verification of cas no
The CAS Registry Mumber 2000-66-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,0,0 and 0 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 2000-66:
(6*2)+(5*0)+(4*0)+(3*0)+(2*6)+(1*6)=30
30 % 10 = 0
So 2000-66-0 is a valid CAS Registry Number.
2000-66-0Relevant articles and documents
Alternative synthetic approaches to rac-progesterone by way of the classic Johnson cationic polycyclization strategy
Slegeris, Rimantas,Dudley, Gregory B.
supporting information, p. 3666 - 3672 (2016/06/06)
Three alternative synthetic entries into Johnson's classic synthesis of rac-progesterone are presented in this manuscript. ent-Progesterone, the non-natural enantiomer of progesterone, has recently been identified as a potential alternative to progesterone for investigations into possible prevention and treatment of traumatic brain injury (TBI). Difficulties in accessing ent-progesterone in large quantities prevent it from being studied more thoroughly. Strategies for producing synthetic rac-progesterone are described and discussed herein.
Direct Formation of the Steroid Nucleus by a Biomimetic Cyclization
Johnson, William S.,McCarry, Brian E.,Markezich, R. L.,Boots, Sharon G.
, p. 352 - 359 (2007/10/02)
The aim of this study was to synthesize the trienynol 3 and to study its cyclization.The substrate was synthesized by a convergent route, the key step being the stereoselective Wittig-Schlosser condensation of the known aldehyde 19 with the phosphorane 18
A synthesis of progesterone from dehydroepiandrosterone.
Raggio,Watt
, p. 1873 - 1875 (2007/10/11)
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