200214-49-9

Basic information

• Product Name: 2-chloro-5-(Boc-amino)benzyl mesylate
• Synonyms: 2-chloro-5-(Boc-amino)benzyl mesylate
• CAS NO: 200214-49-9
• Molecular Weight: 335.809
• Mol File: 200214-49-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-chloro-5-(Boc-amino)benzyl mesylate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-5-(Boc-amino)benzyl mesylate(200214-49-9)
• EPA Substance Registry System: 2-chloro-5-(Boc-amino)benzyl mesylate(200214-49-9)

Safety Data

• Hazardous Substances Data: 200214-49-9(Hazardous Substances Data)

Upstream product

• 89951-56-4 4-chloro-5-hydroxymethyl aniline 
• 80866-80-4 2-chloro-5-nitrobenzyl alcohol 
• 200214-48-8 tert-butyl N-[4-chloro-3-(hydroxymethyl)phenyl]carbamate 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 200214-50-2 (2-chloro-5-(Boc-amino)phenyl)acetonitrile 
• 934477-05-1 C₂₂H₃₀ClN₃O₇S 
• 934477-04-0 2-(5-tert-butoxycarbonylamino-2-chloro-phenyl)-acrylic acid ethyl ester 
• 200214-52-4 ethyl (2-chloro-5-(Boc-amino)phenyl)acetate 
• 409082-02-6 ethyl 2-(5-amino-2-chlorophenyl)acetate 

Relevant articles and documents

3-Mercaptopropionic acids as efficacious inhibitors of activated thrombin activatable fibrinolysis inhibitor (TAFIa)

A novel series of cyclic potent, selective, small molecule, thiol-based inhibitors of activated thrombin activatable fibrinolysis inhibitor (TAFIa) and the crystal structures of TAFIa inhibitors bound to porcine pancreatic carboxypeptidase B are described. Three series of cyclic arginine and lysine mimetic inhibitors vary significantly in their selectivity against other human basic carboxypeptidases, carboxypeptidase N and carboxypeptidase B. (-)2a displays TAFIa IC50 = 3 nM and 600-fold selectivity against CPN. Inhibition of TAFIa with (rac)2a resulted in dose dependent acceleration of human plasma clot lysis in vitro and was efficacious as an adjunct to tPA in an in vivo rabbit jugular vein thrombolysis model.