89951-56-4

Basic information

• Product Name: 5-AMINO-2-CHLOROBENYL ALCOHOL, 97%
• Synonyms: 5-AMINO-2-CHLOROBENYL ALCOHOL, 97%;(5-amino-2-chlorophenyl)methanol;5-AMINO-2-CHLOROBENYL;2-Chloro-5-aminobenzenemethanol;2-Chloro-5-aminobenzyl alcohol;4-Chloro-3-(hydroxymethyl)aniline
• CAS NO: 89951-56-4
• Molecular Formula: C₇H₈ClNO
• Molecular Weight: 157.599
• EINECS: 604-604-1
• Product Categories: Amino Alcohols;Organic Building Blocks;Oxygen Compounds
• Mol File: 89951-56-4.mol
• Article Data: 13

Chemical Properties

• Melting Point: 119-123 °C(lit.)
• Boiling Point: 326 °C at 760 mmHg
• Flash Point: 151 °C
• Appearance: /
• Density: 1.341 g/cm³
• Vapor Pressure: 9.03E-05mmHg at 25°C
• Refractive Index: 1.63
• CAS DataBase Reference: 5-AMINO-2-CHLOROBENYL ALCOHOL, 97%(CAS DataBase Reference)
• NIST Chemistry Reference: 5-AMINO-2-CHLOROBENYL ALCOHOL, 97%(89951-56-4)
• EPA Substance Registry System: 5-AMINO-2-CHLOROBENYL ALCOHOL, 97%(89951-56-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 89951-56-4(Hazardous Substances Data)

Usage

General Description

5-Amino-2-chlorobenyl alcohol, 97%, is a chemical compound with a high purity level of 97%. It is classified as an amine and contains a chlorine atom. 5-AMINO-2-CHLOROBENYL ALCOHOL, 97% is commonly used in the pharmaceutical and chemical industries as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. It is a versatile building block that can be used in the production of a wide range of products. Additionally, it may also have applications in the field of organic synthesis and chemical research. Overall, 5-amino-2-chlorobenyl alcohol, 97%, is a valuable chemical compound with diverse applications in different industries.

InChI:InChI=1/C7H8ClNO/c8-7-2-1-6(9)3-5(7)4-10/h1-3,10H,4,9H2

Upstream product

• 80866-80-4 2-chloro-5-nitrobenzyl alcohol 
• 42122-75-8 methyl 2-chloro-5-aminobenzoate 
• 6361-21-3 2-chloro-5-nitrobenzaldehyde 
• 89-54-3 2-chloro-5-aminobenzoic acid 

Downstream Products

• 105191-40-0 4-chloro-3-(hydroxymethyl)benzonitrile 
• 902140-45-8 5-azido-2-chlorobenzyl alcohol 
• 200214-48-8 tert-butyl N-[4-chloro-3-(hydroxymethyl)phenyl]carbamate 
• 409082-02-6 ethyl 2-(5-amino-2-chlorophenyl)acetate 
• 200214-50-2 (2-chloro-5-(Boc-amino)phenyl)acetonitrile 
• 200214-52-4 ethyl (2-chloro-5-(Boc-amino)phenyl)acetate 
• 200214-49-9 2-chloro-5-(Boc-amino)benzyl mesylate 
• 934477-04-0 2-(5-tert-butoxycarbonylamino-2-chloro-phenyl)-acrylic acid ethyl ester 
• 934477-05-1 C₂₂H₃₀ClN₃O₇S 
• 902140-48-1 5-azido-2-chlorobenzyl chloride 
• 902140-50-5 5-azido-2-chlorobenzylamine 
• 902140-49-2 N-(5-azido-2-chlorobenzyl)phthalimide 
• 902140-51-6 N,N-bis(5-azido-2-bromobenzyl)-N-(5-azido-2-chlorobenzyl)amine 
• 902140-67-4 C₆₂H₅₄Br₂ClN₁₀P₃ 

Relevant articles and documents

Selective Triazenation Reaction (STaR) of Secondary Amines for Tagging Monomethyl Lysine Post-Translational Modifications

Lysine monomethylation (Kme) is an impactful post-translational modification (PTM) responsible for regulating biological processes and implicated in diseases, thus there is great interest in identifying these methylation marks globally. However, the progr

KINASE INHIBITORS

Compounds of formula (I) described herein are p38 MAPK inhibitors and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract

New hits as antagonists of GPR103 identified by HTS

Preclinical data indicate that GPR103 receptor and its endogenous neuropeptides QRFP26 and QRFP43 are involved in appetite regulation. A high throughput screening (HTS) for small molecule GPR103 antagonists was performed with the clinical goal to target weight management by modulation of appetite. A high hit rate from the HTS and initial low confirmation with respect to functional versus affinity data challenged us to revise the established screening cascade. To secure high quality data while increasing throughput, the binding assay was optimized on quality to run at single concentration. This strategy enabled evaluation of a larger fraction of chemical clusters and singletons delivering 17 new compound classes for GPR103 antagonism. Representative compounds from three clusters are presented. One of the identified clusters was further investigated, and an initial structure-activity relationship study is reported. The most potent compound identified had a pIC50 of 7.9 with an improved ligand lipophilic efficiency.