200631-40-9

Basic information

• Product Name: 3,3-DiMethyl-2-tosyl-1,2,3,4-tetrahydroisoquinoline
• Synonyms: 3,3-DiMethyl-2-tosyl-1,2,3,4-tetrahydroisoquinoline
• CAS NO: 200631-40-9
• Molecular Formula: C18H21NO2S
• Molecular Weight: 315.436
• Mol File: 200631-40-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3,3-DiMethyl-2-tosyl-1,2,3,4-tetrahydroisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 3,3-DiMethyl-2-tosyl-1,2,3,4-tetrahydroisoquinoline(200631-40-9)
• EPA Substance Registry System: 3,3-DiMethyl-2-tosyl-1,2,3,4-tetrahydroisoquinoline(200631-40-9)

Safety Data

• Hazardous Substances Data: 200631-40-9(Hazardous Substances Data)

Upstream product

• 109-87-5 Dimethoxymethane 
• 110871-36-8 4-methyl-N-(2-methyl-1-phenylpropan-2-yl)benzenesulfonamide 
• 1268267-77-1 2-isopentylbenzaldehyde 
• 70-55-3 toluene-4-sulfonamide 
• 648895-02-7 (2-(2-methylallyl)phenyl)methanol 
• 17100-66-2 2-(tetrahydropyranyloxy)methylbromobenzene 
• 98-59-9 p-toluenesulfonyl chloride 
• 122-09-8 Phentermin 
• 1197-21-3 phentermine hydrochloride 

Downstream Products

• 28459-83-8 3,3-dimethyl-1,2,3,4-tetrahydroisoquinoline 
• 1400303-74-3 1-(4-(methoxycarbonyl)phenyl)-3,3-dimethyl-3,4-dihydroisoquinoline 2-oxide 
• 1400303-73-2 3,3-dimethyl-1-(3,4,5-trimethoxyphenyl)-3,4-dihydroisoquinoline 2-oxide 
• 1400303-72-1 3,3-dimethyl-1-(p-tolyl)-3,4-dihydroisoquinoline 2-oxide 
• 148671-62-9 3,3-dimethyl-3,4-dihydroisoquinoline N-oxide 
• 28460-55-1 3,3-dimethyl-3,4-dihydroisoquinoline 

Relevant articles and documents

Synthesis of Tetrahydroisoquinolines through an Iron-Catalyzed Cascade: Tandem Alcohol Substitution and Hydroamination

Rapid assembly of saturated nitrogen heterocycles - the synthetically more challenging variants of their aromatic relatives - can expedite the synthesis of biologically relevant molecules. Starting from a benzylic alcohol tethered to an unactivated alkene, an iron-catalyzed tandem alcohol substitution and hydroamination provides access to tetrahydroisoquinolines in a single synthetic step. Using a mild iron-based catalyst, the combination of these operations forms two carbon-nitrogen bonds and provides a unique annulation strategy to access this valuable core.

Concise route to 3-arylisoquinoline skeleton by lewis acid catalyzed c(sp3)-h bond functionalization and its application to formal synthesis of (±)-Tetrahydropalmatine

An expeditious route to furnish an isoquinoline skeleton via hydride shift mediated C-H bond functionalization was developed. In this process, an unusual [1,5]-H shift without the assistance of the adjacent heteroatom took place to produce tetrahydroisoquinoline derivatives in good to excellent chemical yields. The formal synthesis of (±)-tetrahydropalmatine was achieved by exploiting this new transformation.