201002-48-4

Basic information

• Product Name: C₃₇H₅₁N₃O₃
• Synonyms: C₃₇H₅₁N₃O₃
• CAS NO: 201002-48-4
• Molecular Weight: 585.83
• Mol File: 201002-48-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₇H₅₁N₃O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₇H₅₁N₃O₃(201002-48-4)
• EPA Substance Registry System: C₃₇H₅₁N₃O₃(201002-48-4)

Safety Data

• Hazardous Substances Data: 201002-48-4(Hazardous Substances Data)

Upstream product

• 201002-41-7 (2R,3S,4R)-2-azidooctadecane-1,3,4-triol 
• 76-83-5 trityl chloride 

Downstream Products

• 1448529-93-8 (2R,3S,4R)-2-hexacosylamino-3,4-di-O-benzyloctadecanoic acid 
• 202812-11-1 3,4 di-O-benzylphytosphingosine 
• 202812-10-0 (2S,3S,4S)-2-azido-3,4-di-O-benzyl-octadecan-1,3,4-triol 
• 160280-70-6 (2S,3S,4R)-2-hexacosylamino-3,4-di-O-benzyl-1,3,4-octadecanetriol 
• 201002-42-8 C₅₁H₆₃N₃O₃ 

Relevant articles and documents

Design and synthesis of new KRN7000 analogues

Presented by CD1d protein, KRN7000, a potent synthetic α- galactosylceramide, is known to stimulate the iNKT cells to produce different bioactive cytokines. Six new KRN7000 analogues, in which the amide bond in KRN7000 is replaced with O, NH, or ester groups incorporating variation of the acyl chain, or possessing an additional four-atom linker between the galactose and phytosphingosine moiety, were designed and synthesized. The synthetic compounds were evaluated for their ability to stimulate cytokine release and the preliminary structure-activity relationships were discussed. The synthetic strategy will benefit the construction of more KRN7000 derivatives, which may contribute to cytokine profile bias.