20101-92-2

Basic information

• Product Name: 2-(4-CHLOROPHENYL)ACETAMIDE
• Synonyms: Benzeneacetamide, 4-chloro-
• CAS NO: 20101-92-2
• Molecular Formula: C₈H₈ClNO
• Molecular Weight: 169.60822
• Mol File: 20101-92-2.mol
• Article Data: 34

Chemical Properties

• Melting Point: 183-185 °C
• Boiling Point: 344.9±25.0 °C(Predicted)
• Appearance: /
• Density: 1.256±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 16.11±0.40(Predicted)
• CAS DataBase Reference: 2-(4-CHLOROPHENYL)ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-CHLOROPHENYL)ACETAMIDE(20101-92-2)
• EPA Substance Registry System: 2-(4-CHLOROPHENYL)ACETAMIDE(20101-92-2)

Safety Data

• Hazardous Substances Data: 20101-92-2(Hazardous Substances Data)

Usage

General Description

2-(4-chlorophenyl)acetamide is a chemical compound with the molecular formula C8H8ClNO. It is an off-white solid with a molecular weight of 169.61 g/mol. 2-(4-CHLOROPHENYL)ACETAMIDE is used in the pharmaceutical industry as an intermediate in the synthesis of various drugs and bioactive molecules. It is also used in the production of pesticides and other agrochemicals. 2-(4-chlorophenyl)acetamide is known to have a mild to moderate irritant effect on the skin and eyes, and it may cause respiratory irritation if inhaled. It is important to handle this compound with care and use appropriate protective equipment when working with it.

Upstream product

• 99-91-2 para-chloroacetophenone 
• 151-50-8 potassium cyanide 
• 104-83-6 1-Chloro-4-(chloromethyl)benzene 
• 25026-34-0 4-chlorophenacetyl chloride 
• 26069-13-6 2,6-Dimethylen-bicyclo[3.3.1]nonan 
• 140-53-4 p-chlorobenzyl cyanide 
• 52449-43-1 (4-chloro-phenyl)-acetic acid methyl ester 
• 7664-41-7 ammonia 
• 103-81-1 Benzeneacetamide 
• 1878-66-6 4-chlorophenylacetic Acid 
• 6965-39-5 2-(4-chlorophenyl)-N'-hydroxyacetimidamide 
• 1375415-80-7 C₄H₁₁N*C₅H₁₀O₂ 
• 1641-36-7 n-butylammonium acetate 
• 58518-76-6 ((1-(4-chlorophenyl)vinyl)oxy)trimethylsilane 

Downstream Products

• 90842-52-7 N-(2,2,2-trichlor-1-hydroxyethyl)-p-chlorphenylacetamid 
• 95734-12-6 3,4-Bis-(4-chloro-phenyl)-6-phenyl-3,4-dihydro-1H-pyridin-2-one 
• 109329-59-1 3-(4-Chloro-phenyl)-4-pyridin-4-yl-3,4,5,6-tetrahydro-1H-benzo[h]quinolin-2-one 
• 106658-35-9 4-(o-chlorophenyl)-pyrimidine-2,6-dione 
• 95734-18-2 3,6-Bis-(4-chloro-phenyl)-4-phenyl-1H-pyridin-2-one 
• 109329-54-6 4-(3-Chloro-phenyl)-3-(4-chloro-phenyl)-3,4,5,6-tetrahydro-1H-benzo[h]quinolin-2-one 
• 109329-53-5 3,4-Bis-(4-chloro-phenyl)-3,4,5,6-tetrahydro-1H-benzo[h]quinolin-2-one 
• 4843-42-9 3-(1-naphthyl)propiolic acid 
• 109329-55-7 3-(4-Chloro-phenyl)-4-naphthalen-1-yl-3,4,5,6-tetrahydro-1H-benzo[h]quinolin-2-one 
• 109329-57-9 3-(4-Chloro-phenyl)-4-furan-2-yl-3,4,5,6-tetrahydro-1H-benzo[h]quinolin-2-one 
• 109329-56-8 3-(4-Chloro-phenyl)-4-thiophen-2-yl-3,4,5,6-tetrahydro-1H-benzo[h]quinolin-2-one 
• 109329-58-0 3-(4-Chloro-phenyl)-4-pyridin-3-yl-3,4,5,6-tetrahydro-1H-benzo[h]quinolin-2-one 
• 95734-21-7 3-(4-Chloro-phenyl)-4,6-diphenyl-1H-pyridin-2-one 
• 35122-72-6 3-(4-chloro-phenyl)-4-phenyl-3H-pyridine-2,6-dione 

Relevant articles and documents

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A CO2-mediated base catalysis approach for the hydration of triple bonds in ionic liquids

Herein, we report a CO2-mediated base catalysis approach for the activation of triple bonds in ionic liquids (ILs) with anions that can chemically capture CO2 (e.g., azolate, phenolate, and acetate), which can achieve hydration of triple bonds to carbonyl chemicals. It is discovered that the anion-complexed CO2 could abstract one proton from proton resources (e.g., IL cation) and transfer it to the CN or CC bonds via a six-membered ring transition state, thus realizing their hydration. In particular, tetrabutylphosphonium 2-hydroxypyridine shows high efficiency for hydration of nitriles and CC bond-containing compounds under a CO2 atmosphere, affording a series of carbonyl compounds in excellent yields. This catalytic protocol is simple, green, and highly efficient and opens a new way to access carbonyl compounds via triple bond hydration under mild and metal-free conditions.

Direct synthesis of amides from nonactivated carboxylic acids using urea as nitrogen source and Mg(NO3)2or imidazole as catalysts

A new method for the direct synthesis of primary and secondary amides from carboxylic acids is described using Mg(NO3)2·6H2O or imidazole as a low-cost and readily available catalyst, and urea as a stable, and easy to manipulate nitrogen source. This methodology is particularly useful for the direct synthesis of primary and methyl amides avoiding the use of ammonia and methylamine gas which can be tedious to manipulate. Furthermore, the transformation does not require the employment of coupling or activating agents which are commonly required.

Lithiation Substitution of Unprotected Benzyltetrazoles

1H-Tetrazoles occupy an important role in modern medicinal chemistry, but few methods for their modification exist. Many extant protocols require the use of a difficult to remove N-alkyl-protecting group, precluding the products from use as carboxylate bioisosteres, the major role of tetrazoles in pharmaceuticals. We herein report a convenient, protecting-group-free lithiation-substitution protocol for benzylic tetrazoles. Metalation with n-BuLi at 0 °C followed by electrophilic trapping gave a range of α-functionalized benzyltetrazoles in up to 91% yield.