201211-58-7Relevant articles and documents
Solid phase synthesis of polyamine conjugates for the study of trypanothione reductase
Marsh, Ian R.,Bradley, Mark
, p. 17317 - 17334 (2007/10/03)
A number of polyamine scaffolds were synthesised, enabling the facile preparation of a variety of polyamine conjugates using both Boc and Fmoc protecting group strategies. Products were released from the solid support by treatment with either triflic acid/trifluoroacetic acid or trifluoroacetic acid. The trypanosomal metabolite N1, N6-bis(glurathionyl)spermidine [trypanothione], and a range of related analogues were prepared for biological evaluation as previously communicated.