20172-34-3Relevant articles and documents
Direct amide bond formation from carboxylic acids and amines using activated alumina balls as a new, convenient, clean, reusable and low cost heterogeneous catalyst
Ghosh, Sabari,Mukhopadhyay, Chhanda,Bhaumik, Asim,Mondal, John,Mallik, Amit,Sengupta, Sumita
, p. 3220 - 3229,10 (2020/09/16)
For the first time, we have used activated alumina balls (3-5 mm diameter) for amide synthesis from carboxylic acids (unactivated) and amines (unactivated) under neat reaction conditions that produce no toxic by-products and has the advantages of being low-cost, easily available, heterogeneous, reusable and environmentally benign with no troublesome/hazardous disposal of the catalyst.
Efficient microwave access to polysubstituted amidines from imidoylbenzotriazoles
Katritzky, Alan R.,Cai, Chunming,Singh, Sandeep K.
, p. 3375 - 3380 (2007/10/03)
Microwave reactions of primary and secondary amines with imidoylbenzotriazoles 6a-w gave diversely substituted amidines 7a-Aa in 76-94% yields. Convenient preparations of a variety of amides 5a-Ab (87-96%) and imidoylbenzotriazoles 6a-w (56-95%) have also been developed using microwave irradiation under mild conditions and short reaction times. These results demonstrate further the advantages of microwave synthesis and introduce a new application of imidoylbenzotriazoles in the preparation of polysubstituted amidines.