20210-97-3

Basic information

• Product Name: ethylene disalicylate
• Synonyms: ethylene disalicylate;Bis(2-hydroxybenzoic acid)1,2-ethanediyl ester;Ethylene glycol disalicylate;Salicylic acid glycol ester;Einecs 243-604-1;Benzoic acid, 2-hydroxy-, 1,2-ethanediyl ester
• CAS NO: 20210-97-3
• Molecular Formula: C₁₆H₁₄O₆
• Molecular Weight: 302.27876
• EINECS: 243-604-1
• Mol File: 20210-97-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 453.1°C at 760 mmHg
• Flash Point: 166.4°C
• Appearance: /
• Density: 1.355g/cm³
• Vapor Pressure: 7.91E-09mmHg at 25°C
• Refractive Index: 1.614
• CAS DataBase Reference: ethylene disalicylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethylene disalicylate(20210-97-3)
• EPA Substance Registry System: ethylene disalicylate(20210-97-3)

Safety Data

• Hazardous Substances Data: 20210-97-3(Hazardous Substances Data)

Usage

General Description

Ethylene disalicylate is a chemical compound formed from the esterification of two molecules of salicylic acid with ethylene glycol. It is commonly used as a plasticizer in the production of vinyl compounds such as PVC, where it acts as a stabilizer and modifier to improve the flexibility and durability of the material. It has also been utilized as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. Ethylene disalicylate is known for its low toxicity and is considered to be relatively safe for use in consumer products when properly handled and processed. However, like many chemical compounds, it should be used with caution and in accordance with established safety guidelines.

InChI:InChI=1/C16H14O6/c17-13-7-3-1-5-11(13)15(19)21-9-10-22-16(20)12-6-2-4-8-14(12)18/h1-8,17-18H,9-10H2

Upstream product

• 87-28-5 2-hydroxyethyl salicylate 
• 107-21-1 ethylene glycol 
• 69-72-7 salicylic acid 
• 1441-87-8 salicyloyl chloride 
• 528-93-8 silver salicylate 
• 106-93-4 ethylene dibromide 
• 54-21-7 sodium salicylate 
• 107-07-3 2-chloro-ethanol 
• 119-36-8 methyl salicylate 
• 6315-52-2 1,2-bis-tosyloxyethane 

Downstream Products

• 136437-20-2 5-nitro-1,2-bis(salicyloyloxy)ethane 
• 136437-22-4 3',5''-dinitro-1,2-bis(salicyloyloxy)ethane 
• 136437-21-3 5',5''-dinitro-1,2-bis(salicyloyloxy)ethane 

Relevant articles and documents

The role of copper ions in Tb(III) luminescence sensitization in heterometallic complexes with podands

It has been demonstrated that copper-induced terbium(III) luminescence sensitization in heterometallic complexes with hydrazine-containing podands is caused by the ligand ring closure and joint coordination of both metal ions to the carbonyl oxygen atoms

Synthesis and biological evaluation of some new 2-oxazoline and salicylic acid derivatives

Starting from methyl salicylate and 2-amino-2-(hydroxymethyl)propane-1,3- diol 1a, or 2-amino- 2-methylpropane-1-ol 1b, the 2-oxazoline derivatives 2a, 2b or 3, as well as mono- 4a and 4b and bis- 5a and 5b derivatives of salicylic acid were synthesized. Reactions were performed by microwave irradiation in the presence of tetrabutylammonium bromide or metallic sodium as catalyst, as well as by conventional heating. Microwave-induced reaction of some diols, diamines and amino alcohols with methyl salicylate gave mono- and/or bis- derivatives of salicylic acid 4c, 5c, 5d, 6c, 8c, 7a, 7b, 8a and 8b. The mono- and bis-salicyloyl derivatives 4c, 5c and 5d were transformed to the corresponding phenyl-azo derivatives 9, 10c and 10d. The structure of compound 3 was proved by the X-ray analysis and the R-configuration on its stereocenter was confirmed. The antioxidant and cytotoxic activities of the synthesized derivatives were evaluated in a series of in vitro tests. Compounds 5d, 8b and 8c exhibited very strong activity against hydroxyl radical. Six 4c, 5d, 8a-c, 10c of 16 tested compounds inhibited growth of MDA-MB-231 cells at a nanomolar concentration. Compounds 8c and 10c showed high cytotoxicity against MCF7 cells, whereas compounds 4c, 5d, 8a-c and 10d showed high activity against K562 cells. ARKAT-USA, Inc.