202197-31-7

Basic information

• Product Name: 5-Amino-1-(3-fluorobenzyl)indazole
• Synonyms: 5-Amino-1-(3-fluorobenzyl)indazole;1-(3-fluorobenzyl)-1H-indazol-5-aMine;1-(3-Fluoro-benzyl)-1H-indazol-5-ylamine
• CAS NO: 202197-31-7
• Molecular Formula: C₁₄H₁₂FN₃
• Molecular Weight: 241.27
• Product Categories: API intermediates
• Mol File: 202197-31-7.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 438.1°C at 760 mmHg
• Flash Point: 218.7°C
• Appearance: /
• Density: 1.28g/cm³
• Vapor Pressure: 7.11E-08mmHg at 25°C
• Refractive Index: 1.647
• CAS DataBase Reference: 5-Amino-1-(3-fluorobenzyl)indazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Amino-1-(3-fluorobenzyl)indazole(202197-31-7)
• EPA Substance Registry System: 5-Amino-1-(3-fluorobenzyl)indazole(202197-31-7)

Safety Data

• Hazardous Substances Data: 202197-31-7(Hazardous Substances Data)

Usage

General Description

5-Amino-1-(3-fluorobenzyl)indazole is a chemical compound with the molecular formula C15H12N3F. It is a derivative of indazole, a heterocyclic aromatic organic compound. This particular compound contains a substituent group of 5-amino-1-(3-fluorobenzyl), which is attached to the indazole core structure. It is commonly used in research and pharmaceutical applications, particularly in the development of pharmaceutical drugs and as a biochemical tool for studying various biological processes. 5-Amino-1-(3-fluorobenzyl)indazole may have potential therapeutic properties, and its synthesis and properties are the subject of ongoing scientific study.

InChI:InChI=1/C14H12FN3/c15-12-3-1-2-10(6-12)9-18-14-5-4-13(16)7-11(14)8-17-18/h1-8H,9,16H2

Upstream product

• 529508-58-5 1-(3-fluorobenzyl)-5-nitro-1H-carbazole 
• 456-42-8 m-fluorobenzyl chloride 
• 5401-94-5 5-nitroindazole 
• 884874-01-5 2-(3-fluorobenzyl)-5-nitro-2H-indazole 
• 456-41-7 1-(Bromomethyl)-3-fluorobenzene 

Downstream Products

• 230955-59-6 4-((1-(3-fluorobenzyl)-1H-indazol-5-yl)amino)quinazolin-6-yl acetate 
• 856667-79-3 ethyl 4-[1-(3-fluoro-benzyl)-1H-indazol-5-ylamino]-5-methyl-pyrrolo[2,1-f][1,2,4]triazine-6-carboxylate 
• 900795-36-0 methyl 4-(1-(3-fluorobenzyl)-1H-indazol-5-ylamino)-6-methylpyrrolo[1,2-f][1,2,4]triazine-5-carboxylate 
• 529509-61-3 {4-[1-(3-fluoro-benzyl)-1H-indazol-5-ylamino]-pyrrolo[2,1-f][1,2,4]triazin-5-yl}-methanol 
• 529508-59-6 [1-(3-fluoro-benzyl)-1H-indazol-5-yl]-(5-phenylsulfanylmethyl-pyrrolo[2,1-f][1,2,4]triazin-4-yl)-amine 
• 697299-99-3 [1-(3-fluoro-benzyl)-1H-indazol-5-yl]-(6-iodo-quinazolin-4-yl)-amine hydrochloride 
• 529509-71-5 4-{4-[1-(3-fluoro-benzyl)-1H-indazol-5-ylamino]-pyrrolo[2,1-f][1,2,4]triazin-5-ylmethoxy}-piperidine-1-carboxylic acid tert-butyl ester 
• 202197-88-4 (1-(3-Fluorobenzyl)-1H-indazol-5-yl)-(6-(5-methyl-1,3,4-oxadiazol-2-yl)-quinazolin-4-yl)-amine hydrochloride 
• 202197-13-5 (1-(3-Fluoro-benzyl)-1H-indazol-5-yl)-(6-(5-trifluoromethyl-1,3,4-oxadiazol-2-yl)-quinazolin-4-yl)-amine 
• 202273-14-1 N₄-(1-(3-Fluoro-benzyl)-1H-indazol-5-yl)-N₆,N₆-dimethyl-pyrido[3,4-d]pyrimidine-4,6-diamine hydrochloride 
• 202273-19-6 (1-(3-Fluoro-benzyl)-1H-indazol-5-yl)-(6-(5-methyl-1,3,4-oxadiazol-2-yl)-pyrido[3,4-d]pyrimidin-4-yl)-amine hydrochloride 
• 914308-84-2 4-chloro-6-[1-(3-fluoro-benzyl)-1H-indazol-5-ylamino]-pyrimidine-5-carbonitrile 
• 744194-19-2 5-fluoro-N-[1-(3-fluorobenzyl)-1H-indazol-5-yl]quinazolin-4-amine 
• 878018-69-0 N-[1-(3-fluorobenzyl)-1H-indazol-5-yl]amino-5,8-dihydro-6H-spiro[1-benzothieno[2,3-d]pyrimidine-7,2'-[1,3]dioxolan]-4-amine hydrochloride 

Relevant articles and documents

Hetero-aromatic compound and its use in medicine

The invention provides a hetero-aromatic compound or a stereisomer, geometric isomer, tautomer, despinner, nitrogen oxide, hydrate, solvate, metabolite, metabolism precursor and pharmaceutically acceptable salt or prodrug thereof, which is used for treating proliferative diseases. The invention also discloses a pharmaceutical composition containing the compound and an application of the compound or pharmaceutical composition thereof in preparation of a medicine for treating proliferative diseases.

QUINAZOLINE COMPOUNDS

Provided are certain quinazoline compounds, compositions thereof and methods of use thereof. These quinazoline compounds can effectively inhibit the overexpression and/or overactivity of epidermal growth factor receptor (EGFR).

Synthesis and cytotoxic activity of 2,5-disubstituted pyrimido[5,4-c] quinoline derivatives

A series of 2,5-disubstituted pyrimido[5,4-c]quinoline derivatives were synthesized and their cytotoxic activity against H460, HT-29 and MDA-MB-231 cell lines was evaluated in vitro. It was found that most of the tested compounds especially compound 17, s