202341-04-6Relevant articles and documents
Effect of the Ito activator NS5806 on cloned Kv4 channels depends on the accessory protein KChIP2
Lundby,Jespersen,Schmitt,Grunnet,Olesen,Cordeiro, Jm,Calloe
, p. 2028 - 2044 (2010)
BACKGROUND AND PURPOSE The compound NS5806 increases the transient outward current (Ito) in canine ventricular cardiomyocytes and slows current decay. In human and canine ventricle, Ito is thought to be mediated by KV4.3 a
DIARYLUREA DERIVATIVES AND THEIR USE AS CHLORIDE CHANNEL BLOCKERS
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Page 36, (2008/06/13)
The present invention relates to novel diarylurea derivatives useful as chloride channel blockers. In other aspects the invention relates to the use of these compounds in a method for therapy, such as for the treatment of bone metabolic diseases, diseases responsive to modulation of the mast cell or basophil activity, diseases responsive to inhibition of angiogenesis, or sickle cell anaemia, and to pharmaceutical compositions comprising the compounds of the invention.