68385-95-5

Basic information

• Product Name: 2-AMINO-3,5-DIBROMOBENZONITRILE
• Synonyms: 3,5-DIBROMOANTHRANILONITRILE;2-AMINO-3,5-DIBROMOBENZONITRILE;BUTTPARK 37\12-53;2-Amino-3,5-Dibromobenzonitrile 3,5-Dibromo-2-Aminobenzonitrile;3,5-Dibromo-2-Aminobenzonitrile;2-Amino-3,5-dibromobenzonitrile,99%
• CAS NO: 68385-95-5
• Molecular Formula: C₇H₄Br₂N₂
• Molecular Weight: 275.93
• Product Categories: Aromatic Nitriles;C6 to C7;Cyanides/Nitriles;Nitrogen Compounds;Building Blocks;C6 to C7;Chemical Synthesis;Nitrogen Compounds;Organic Building Blocks
• Mol File: 68385-95-5.mol
• Article Data: 17

Chemical Properties

• Melting Point: 152-156 °C(lit.)
• Boiling Point: 301.2 °C at 760 mmHg
• Flash Point: 136 °C
• Appearance: /Solid
• Density: 1.9911 (rough estimate)
• Vapor Pressure: 0.00107mmHg at 25°C
• Refractive Index: 1.6300 (estimate)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: -0.95±0.10(Predicted)
• CAS DataBase Reference: 2-AMINO-3,5-DIBROMOBENZONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-3,5-DIBROMOBENZONITRILE(68385-95-5)
• EPA Substance Registry System: 2-AMINO-3,5-DIBROMOBENZONITRILE(68385-95-5)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 36/37/38-20/21/22
• Safety Statements: 36/37/39-26
• WGK Germany: 3
• Hazardous Substances Data: 68385-95-5(Hazardous Substances Data)

Usage

Chemical Properties

pinkish-brown or reddish-brown powder

InChI:InChI=1/C7H4Br2N2/c8-5-1-4(3-10)7(11)6(9)2-5/h1-2H,11H2

Upstream product

• 1885-29-6 anthranilic acid nitrile 
• 50910-55-9 3,5-dibromo-2-amino benzaldehyde 

Downstream Products

• 17518-85-3 6,8-dibromo-3,4-dihydro-4-oxo-quinazoline 
• 97165-77-0 3,5-dibromobenzonitrile 
• 609-85-8 2-amino-3,5-dibromobenzoic acid 
• 82326-77-0 6,8-Dibromo-2-methyl-1,3-4(3H)-quinazolinone 
• 106874-98-0 N-(2-bromopropionyl)-3,5-dibromo-N-methyl-2-cyanoaniline 
• 106874-92-4 3,5-dibromo-N-methylanthranilonitrile 
• 351425-98-4 2,4-dibromo-6-(4,5-dihydro-1H-imidazol-2-yl)-phenylamine 
• 353754-59-3 N-[(4-nitrophenyl)thio]-2,4-diphenyl-6-cyanoaniline 
• 353754-60-6 N-[(2,4-dichlorophenyl)thio]-2,4-diphenyl-6-cyanoaniline 
• 353754-61-7 N-[(4-nitrophenyl)thio]-2,4-bis(4-chlorophenyl)-6-cyanoaniline 
• 353754-62-8 N-[(2,4-dichlorophenyl)thio]-2,4-bis(4-chlorophenyl)-6-cyanoaniline 
• 618-58-6 3,5-dibromobenzoic acid 
• 202341-04-6 2,4-dibromo-6-(1H-tetrazol-5-yl)aniline 
• 1221448-63-0 2-(N-allylamino)-3,5-dibromobenzonitrile 

Relevant articles and documents

DIPHENYLUREA COMPOUND DERIVATIVE

To provide a novel diphenylurea compound derivative that is involved in the functional regulation of an ion transporter of a plant.SOLUTION: The present invention relates to a diphenylurea compound derivative represented by the following formula (1) (each

FUNCTION CONTROL AGENT FOR PLANT POTASSIUM ION TRANSPORTER, AND METHOD OF GROWING PLANT

PROBLEM TO BE SOLVED: To provide: a function control agent for a plant potassium ion transporter by screening diphenylurea compound derivatives having function control activity targeting a transporter of a plant; and a method of growing a plant body modif

Synthesis, characterization, and SAR of arylated indenoquinoline-based cholinesterase and carbonic anhydrase inhibitors

We report the synthesis of bromoindenoquinolines (15a–f) by Friedlander reactions in low yields (13–50%) and the conversion of the corresponding phenyl-substituted indenoquinoline derivatives 16–21 in high yields (80–96%) by Suzuki coupling reactions. To explore the structure–activity relationship (SAR), their inhibition potentials to inhibit acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and human carbonic anhydrase cyctosolic (hCA I and II) enzymes were determined. Monophenyl (16–18) indenoquinolines significantly inhibited the AChE and BChE enzymes in ranges of IC50 37–57 nM and 84–93 nM, respectively, compared with their starting materials 15a–c and reference compounds (galanthamine and tacrine). On the other hand, these novel arylated indenoquinoline-based derivatives were effective inhibitors of the BChE, hCA I and II, BChE and AChE enzymes with Ki values in the range of 37 ± 2.04 to 88640 ± 1990 nM for AChE, 120.94 ± 37.06 to 1150.95 ± 304.48 nM for hCA I, 267.58 ± 98.05 to 1568.16 ± 438.67 nM for hCA II, and 84 ± 3.86 to 144120 ± 2910 nM for BChE. As a result, monophenyl indenoquinolines 16–18 may have promising anti-Alzheimer drug potential and 3,8-dibromoindenoquinoline amine (15f) can be novel hCA I and hCA II enzyme inhibitors.