609-85-8Relevant articles and documents
Comparative biological study between quinazolinyl–triazinyl semicarbazide and thiosemicarbazide hybrid derivatives
Patel, Janki J.,Modh, Rahul P.,Asamdi, Manjoorahmed,Chikhalia, Kishor H.
, p. 2271 - 2287 (2020/07/04)
Abstract: Practical synthesis and biological activities of quinazolinyl–triazinyl semicarbazides (10a–j) and quinazolinyl–triazinyl thiosemicarbazides (11a–j) have been described. The novel semicarbazides and thiosemicarbazides were prepared by condensati
Preparation method of 3,5-dibromo-2-aminobenzoic acid
-
Paragraph 0038-0073, (2019/01/16)
The invention discloses a preparation method of 3,5-dibromo-2-aminobenzoic acid. The preparation method comprises the following steps: (I) performing in-situ oxidation on bromide with an oxidant underan acidic condition, and carrying out a bromination reaction on phthalimide to obtain N-bromophthalimide; (II) performing Hoffmann degradation on the N-bromophthalimide under the action of alkali toobtain 2-aminobenzoic acid and bromoanion; (III) further adding an appropriate amount of bromide and oxidant, and carrying out a bromination reaction on the 2-aminobenzoic acid to obtain the product,namely, 3,5-dibromo-2-aminobenzoic acid. The preparation method has the advantages of environment-friendly reaction system, simple, convenient and safe reaction operation, low cost, high reaction selectivity and high product yield and the like.
Preparation method for ambroxol hydrochloride intermediate 3,5-dibromo-2-aminobenzoic acid
-
Paragraph 0021; 0032; 0033; 0035; 0039, (2019/01/14)
The invention discloses a preparation method for an ambroxol hydrochloride intermediate 3,5-dibromo-2-aminobenzoic acid. The method enables the ambroxol hydrochloride intermediate 3,5-dibromo-2-aminobenzoic acid to be obtained through the following two-st