202390-84-9

Basic information

• Product Name: Methyl (4S,5R)-3-benzoyl-2,2-dimethyl-4-phenyl-1,3-oxazolidine-5-carboxylate
• Synonyms: Methyl (4S,5R)-3-benzoyl-2,2-dimethyl-4-phenyl-1,3-oxazolidine-5-carboxylate
• CAS NO: 202390-84-9
• Molecular Weight: 339.391
• Mol File: 202390-84-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Methyl (4S,5R)-3-benzoyl-2,2-dimethyl-4-phenyl-1,3-oxazolidine-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl (4S,5R)-3-benzoyl-2,2-dimethyl-4-phenyl-1,3-oxazolidine-5-carboxylate(202390-84-9)
• EPA Substance Registry System: Methyl (4S,5R)-3-benzoyl-2,2-dimethyl-4-phenyl-1,3-oxazolidine-5-carboxylate(202390-84-9)

Safety Data

• Hazardous Substances Data: 202390-84-9(Hazardous Substances Data)

Upstream product

• 202390-83-8 5-Ethyl (2R,3S)-3-benzoylamino-2-benzyloxy-3-phenylpropanethioate 
• 222727-06-2 S-Ethyl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanethioate 
• 202390-82-7 5-Ethyl (2R,3S)-3-amino-2-benzyloxy-3-phenylpropanethioate 
• 129320-33-8 5-Ethyl (2R,3R)-2-benzyloxy-3-hydroxy-3-phenylpropanethioate 
• 195624-97-6 (2R,3S)-3-acetylamino-2-hydroxy-3-phenylpropanoic acid isopropyl ester 
• 157240-36-3 (2R,3S)-3-phenylisoserine methyl ester 
• 98-88-4 benzoyl chloride 
• 136561-53-0 (2R,3S)-2-hydroxy-3-amino-3-phenylpropionic acid 
• 60512-85-8 (E)-isopropyl cinnamate 
• 116-11-0 2-Methoxypropene 
• 32981-85-4 methyl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoate 

Downstream Products

• 153652-70-1 (4S,5R)-3-Benzoyl-2,2-dimethyl-4-phenyl-1,3-oxazolidine-5-carboxylic acid 

Relevant articles and documents

The design and synthesis of guanosine compounds with in vitro activity against the colon cancer cell line SW480: Non-taxane derived mimics of taxol?

In the course of our investigation into the use of taxol as a lead compound to design new molecules with anti-cancer activity, we have synthesized four compounds based on protected guanosine coupled to taxol isoserine side-chain analogues. These analogues show in vitro anti-cancer activity against the colon cancer cell line SW480 that their constituent parts do not.

Total asymmetric synthesis of taxol by dehydration condensation between 7-TES baccatin III and protected N-benzoylphenylisoserines prepared by enantioselective aldol reaction

Total asymmetric synthesis of Taxol was completed by dehydration condensation between a protected N-benzoylphenylisoserine 4 or 9 and 7-TES baccatin in which was prepared from 8-membered ring enone. Taxol side chains 4, 7, 9 and 11, optically active protected N-benzoylphenylisoserines, were successfully synthesized by enantioselective aldol reaction from two achiral starting materials, benzaldehyde and an enol silyl ether derived from S-ethyl benzyloxyethanethioate.