202410-99-9

Basic information

• Product Name: Boc-Pro-Ala-Lys(Z)-OBzl
• Synonyms: Boc-Pro-Ala-Lys(Z)-OBzl
• CAS NO: 202410-99-9
• Molecular Weight: 638.761
• Mol File: 202410-99-9.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Boc-Pro-Ala-Lys(Z)-OBzl(CAS DataBase Reference)
• NIST Chemistry Reference: Boc-Pro-Ala-Lys(Z)-OBzl(202410-99-9)
• EPA Substance Registry System: Boc-Pro-Ala-Lys(Z)-OBzl(202410-99-9)

Safety Data

• Hazardous Substances Data: 202410-99-9(Hazardous Substances Data)

Upstream product

• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 24458-14-8 Lys(Z)-OBzl 
• 36301-70-9 (S)?2?[(S)?1?carboxyethylcarbamoyl]pyrrolidine?1?carboxylic acid tert?butyl ester 
• 52616-95-2 Boc-Pro-Ala-OBzl 
• 100-39-0 benzyl bromide 
• 77236-13-6 N-α-tert-Butyloxycarbonyl-N-ε-carbobenzoxy-L-lysine benzyl ester 
• 114856-02-9 Boc-Ala-Lys(Z)-OBzl 
• 6366-70-7 N^ε-carbobenzoxy-L-lysine benzyl ester hydrochloride 
• 2389-45-9 Boc-Lys(Z)-OH 
• 92917-67-4 (S)-2-((S)-2-Amino-propionylamino)-6-benzyloxycarbonylamino-hexanoic acid benzyl ester 
• 68641-29-2 N^α-Boc-Pro-OBt 

Downstream Products

• 713524-12-0 Boc-Gly-Arg(NO₂)-Pro-Ala-Lys(Z)-OBzl 
• 713524-10-8 Boc-Ala-Arg(NO₂)-Pro-Ala-Lys(Z)-OBzl 
• 663954-94-7 Boc-Arg(NO₂)-Pro-Ala-Lys(Z)-OBzl 
• 202411-08-3 Boc-Gln-Arg(Tos)-Pro-Ala-Lys(Z)-OH 
• 202411-07-2 Boc-Ala-Arg(Tos)-Pro-Ala-Lys(Z)-OH 
• 544477-17-0 Boc-Gly-Arg(Tos)-Pro-Ala-Lys(Z)-OBzl 
• 202411-04-9 Boc-Gln-Arg(Tos)-Pro-Ala-Lys(Z)-OBzl 

Relevant articles and documents

DHDMIQK(KAP): A novel nano-delivery system of dihydroxyl-tetrahydro-isoquinoline-3-carboxylic acid and KPAK towards the thrombus

Vascular thrombosis is a major risk of the onset of stroke and so novel therapeutic candidates have been attracting interest. In this context, here docking based computer assisted screening and mesoscale simulation were used to design N-[(S)-6,7-dihydroxy-1,1-dimethyl-1,2,3,4-tetrahydroisoquinoline-3-carbonyl]-Lys(Pro-Ala-Lys), DHDMIQK(KAP), for inhibiting P-selectin expression. In vitro, 1 nM of DHDMIQK(KAP) effectively down-regulated P-selectin expression. In water, in rat plasma and in the solid state DHDMIQK(KAP) formed nanoparticles of a size capable of suitable delivery in the blood circulation. FT-MS and NOESY 2D NMR spectra showed DHDMIQK(KAP) formed hexamers, identified the intermolecular interactions of the hexamer, and assigned the hexamer a butterfly like conformation. Transmission electron microscopy, scanning electron microscopy and atomic force microscopy (AFM) imaged DHDMIQK(KAP) forming size-suitable nanoparticles for safe delivery in the blood circulation. In particular, AFM images showed that the nanoparticles effectively adhered onto the surfaces of the platelets. In vivo DHDMIQK(KAP) lysed the thrombus and inhibited thrombosis with a minimal effective dose of 0.01 nmol kg-1. FT-MS spectrum analyses defined a specific distribution of DHDMIQK(KAP) in the thrombus, but not in the blood and vital organs. Therefore, DHDMIQK(KAP) should be a novel nano-delivery system of 6,7-dihydroxyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid and KPAK to target the thrombus.

NOVEL COMPOUND WITH EFFECTS OF THROMBOLYSIS, FREE RADICAL SCAVENGING AND THROMBUS-TARGETING AS WELL AS PREPARATION METHOD AND USE THEREOF

The present invention discloses a novel compound with effects of thrombolysis, free radical scavenging and thrombus-targeting, as well as a preparation method and use thereof. The compound is a ternary conjugate formed by conjugating a thrombolytic peptide, a free radical scavenger and a thrombus-targeting/antithrombotic peptide together via a linking arm. The present invention also discloses a pharmaceutical composition containing the compounds, wherein the compounds form a nanospherical structure.

Synthesis and biological activity of nitronyl nitroxide containing peptides

[1-(1′,3′-Dioxyl-4′,4′,5′, 5′-tetramethyldihydroimidazol-2-yl)-phenyl-4-yl]oxyacetic acid (4), a nitronyl nitroxide, and its peptide derivatives, N-[1-(1′,3′-dioxyl- 4′,4′,5′,5′-tetramethyldihydroimidazol-2-yl) -phenyl-4-yl]oxyacetyl-ARPAK (9a), -GRPAK (9b), and -QRPAK (9c), were synthesized and characterized. Judging from the results of electron spin resonance analysis, the newly synthesized nitronyl nitroxide containing peptides, 9a, 9b, and 9c, demonstrated the characteristics of free radicals. The free radical scavenging activities of 9a, 9b, and 9c were assessed using in vitro free radical scavenging tests. The thrombolysis effect of 9a, 9b, and 9c was evaluated using an euglobulin clot lysis test, a fibrinolytic lysis test, and in vivo thrombolysis tests. Results indicated that these nitronyl nitroxide containing peptides possessed both free radical scavenging activity and thrombolytic activity.