52616-95-2

Basic information

• Product Name: benzyl 1-(tert-butoxycarbonyl)prolylalaninate
• CAS NO: 52616-95-2
• Molecular Formula: C₂₀H₂₈N₂O₅
• Molecular Weight: 376.4467
• Mol File: 52616-95-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 526.7°C at 760 mmHg
• Flash Point: 272.3°C
• Density: 1.172g/cm³
• Vapor Pressure: 3.51E-11mmHg at 25°C
• Refractive Index: 1.533
• CAS DataBase Reference: benzyl 1-(tert-butoxycarbonyl)prolylalaninate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl 1-(tert-butoxycarbonyl)prolylalaninate(52616-95-2)
• EPA Substance Registry System: benzyl 1-(tert-butoxycarbonyl)prolylalaninate(52616-95-2)

Safety Data

• Hazardous Substances Data: 52616-95-2(Hazardous Substances Data)

Upstream product

• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 42854-62-6 L-alanine benzyl ester p-toluenesulfonate 
• 17831-01-5 H-Ala-OBzl 
• 126400-95-1 N-(tert-butoxycarbonyl)-L-alanine benzyl ester 
• 5557-81-3 L-alanine benzyl ester hydrochloride 
• 147-85-3 L-proline 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 99783-41-2 Pro-Ala-OBzl hydrochloride 
• 70626-62-9 H-L-Pro-L-Ala-OBn 
• 85250-32-4 Boc-Glu(OBzl)-Pro-Ala-OBzl 
• 85250-34-6 Boc-Glu(OBzl)-Glu(OBzl)-Pro-Ala-OBzl 
• 85250-35-7 Boc-Leu-Glu(OBzl)-Glu(OBzl)-Pro-Ala-OBzl 
• 202410-99-9 Boc-Pro-Ala-Lys(Z)-OBzl 
• 36357-32-1 (3S,8aS)-3-methylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione 

Relevant articles and documents

Glycopeptide derivatives for the preservation and protection of biological materials and microorganisms

The present invention relates to a compound of the following formula (I): in which at least one and only one group chosen among R5, R6 and R7 is a group of the following formula: The present invention relates also to uses

DHDMIQK(KAP): A novel nano-delivery system of dihydroxyl-tetrahydro-isoquinoline-3-carboxylic acid and KPAK towards the thrombus

Vascular thrombosis is a major risk of the onset of stroke and so novel therapeutic candidates have been attracting interest. In this context, here docking based computer assisted screening and mesoscale simulation were used to design N-[(S)-6,7-dihydroxy-1,1-dimethyl-1,2,3,4-tetrahydroisoquinoline-3-carbonyl]-Lys(Pro-Ala-Lys), DHDMIQK(KAP), for inhibiting P-selectin expression. In vitro, 1 nM of DHDMIQK(KAP) effectively down-regulated P-selectin expression. In water, in rat plasma and in the solid state DHDMIQK(KAP) formed nanoparticles of a size capable of suitable delivery in the blood circulation. FT-MS and NOESY 2D NMR spectra showed DHDMIQK(KAP) formed hexamers, identified the intermolecular interactions of the hexamer, and assigned the hexamer a butterfly like conformation. Transmission electron microscopy, scanning electron microscopy and atomic force microscopy (AFM) imaged DHDMIQK(KAP) forming size-suitable nanoparticles for safe delivery in the blood circulation. In particular, AFM images showed that the nanoparticles effectively adhered onto the surfaces of the platelets. In vivo DHDMIQK(KAP) lysed the thrombus and inhibited thrombosis with a minimal effective dose of 0.01 nmol kg-1. FT-MS spectrum analyses defined a specific distribution of DHDMIQK(KAP) in the thrombus, but not in the blood and vital organs. Therefore, DHDMIQK(KAP) should be a novel nano-delivery system of 6,7-dihydroxyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid and KPAK to target the thrombus.

Carboline-3-carboxylic acid modified related sequences of Ala-Arg-Pro-Ala-Lys, their synthesis and use as thromobolytic agent

The present invention relates to the protected intermediates and the deprotected products of P6A, related to the protected pseudopeptides introducing the protected intermediateds of P6A to 3S-(2-Boc)-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid and the deprotected pseudopeptides, related to the protected pseudopeptides introducing the protected intermediateds of P6A to 3S-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid benzyl ester, related to the methods for their preparation, and related to their use as the thrombolytic agents.