203436-46-8

Basic information

• Product Name: 1H-Purin-6-amine, N-([1,1'-biphenyl]-4-ylmethyl)-2-chloro-
• CAS NO: 203436-46-8
• Molecular Formula: C18H14ClN5
• Molecular Weight: 335.796
• Mol File: 203436-46-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1H-Purin-6-amine, N-([1,1'-biphenyl]-4-ylmethyl)-2-chloro-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Purin-6-amine, N-([1,1'-biphenyl]-4-ylmethyl)-2-chloro-(203436-46-8)
• EPA Substance Registry System: 1H-Purin-6-amine, N-([1,1'-biphenyl]-4-ylmethyl)-2-chloro-(203436-46-8)

Safety Data

• Hazardous Substances Data: 203436-46-8(Hazardous Substances Data)

Upstream product

• 712-76-5 N-(4-phenyl)benzylamine 
• 5451-40-1 2,6 dichloropurine 

Downstream Products

• 294648-35-4 N-(biphenyl-4-ylmethyl)-2-chloro-9-isopropyl-9H-purin-6-amine 
• 441055-19-2 C₂₁H₁₈ClN₅ 
• 441055-17-0 C₂₃H₂₂ClN₅ 
• 441055-09-0 C₂₀H₁₈ClN₅ 
• 441055-11-4 N-(biphenyl-4-ylmethyl)-2-chloro-9-methyl-9H-purin-6-amine 
• 441055-14-7 N-(biphenyl-4-ylmethyl)-2-chloro-9-propyl-9H-purin-6-amine 
• 441055-21-6 C₂₂H₂₂ClN₅ 

Relevant articles and documents

Biaryl purine derivatives as potent antiproliferative agents: Inhibitors of cyclin dependent kinases. Part I

The introduction of an aryl ring onto the 4-position of the C-6 benzyl amino group of the Cdk inhibitor roscovitine (2), maintained the potent Cdk inhibition demonstrated by roscovitine (2) as well as greatly improving the antiproliferative activity. A series of C-6 biarylmethylamino derivatives was prepared addressing modifications on the C-6 biaryl rings, N-9 and C-2 positions to provide compounds that displayed potent cytotoxic activity against tumor cell lines. In particular, derivative 21h demonstrated a >750-fold improvement in the growth inhibition of HeLa cells compared to roscovitine (2).