441055-21-6

Basic information

• Product Name: 9H-Purin-6-amine, N-([1,1'-biphenyl]-4-ylmethyl)-2-chloro-9-(1-methylpropyl)-
• CAS NO: 441055-21-6
• Molecular Formula: C22H22ClN5
• Molecular Weight: 391.903
• Mol File: 441055-21-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 9H-Purin-6-amine, N-([1,1'-biphenyl]-4-ylmethyl)-2-chloro-9-(1-methylpropyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 9H-Purin-6-amine, N-([1,1'-biphenyl]-4-ylmethyl)-2-chloro-9-(1-methylpropyl)-(441055-21-6)
• EPA Substance Registry System: 9H-Purin-6-amine, N-([1,1'-biphenyl]-4-ylmethyl)-2-chloro-9-(1-methylpropyl)-(441055-21-6)

Safety Data

• Hazardous Substances Data: 441055-21-6(Hazardous Substances Data)

Upstream product

• 203436-46-8 Biphenyl-4-ylmethyl-(2-chloro-9H-purin-6-yl)-amine 

Relevant articles and documents

Biaryl purine derivatives as potent antiproliferative agents: Inhibitors of cyclin dependent kinases. Part I

The introduction of an aryl ring onto the 4-position of the C-6 benzyl amino group of the Cdk inhibitor roscovitine (2), maintained the potent Cdk inhibition demonstrated by roscovitine (2) as well as greatly improving the antiproliferative activity. A series of C-6 biarylmethylamino derivatives was prepared addressing modifications on the C-6 biaryl rings, N-9 and C-2 positions to provide compounds that displayed potent cytotoxic activity against tumor cell lines. In particular, derivative 21h demonstrated a >750-fold improvement in the growth inhibition of HeLa cells compared to roscovitine (2).