20358-08-1

Basic information

• Product Name: Benzothiazole, 2-amino-7-fluoro- (8CI)
• Synonyms: Benzothiazole, 2-amino-7-fluoro- (8CI);2-amino-7-fluorobenzothiazole;2-AMINO-7-FLUORO-BENZOTHIAZOLE HBr;2-Benzothiazolamine,7-fluoro-;7-Fluorobenzo[d]thiazol-2-amine
• CAS NO: 20358-08-1
• Molecular Formula: C₇H₅FN₂S
• Molecular Weight: 168.1914032
• Product Categories: BENZOTHIAZOLE
• Mol File: 20358-08-1.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: Benzothiazole, 2-amino-7-fluoro- (8CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzothiazole, 2-amino-7-fluoro- (8CI)(20358-08-1)
• EPA Substance Registry System: Benzothiazole, 2-amino-7-fluoro- (8CI)(20358-08-1)

Safety Data

• Hazardous Substances Data: 20358-08-1(Hazardous Substances Data)

Usage

General Description

Benzothiazole, 2-amino-7-fluoro- (8CI) is a chemical compound that belongs to the class of organic compounds known as benzothiazoles. It is a derivative of benzothiazole with a fluorine atom attached to the 7th position and an amino group at the 2nd position. Benzothiazole, 2-amino-7-fluoro- (8CI) has potential medicinal properties and is used in the development of pharmaceutical drugs. It is also used as a building block for the synthesis of various other organic compounds. Due to its unique structure and functional groups, Benzothiazole, 2-amino-7-fluoro- (8CI) has potential applications in the field of medicinal chemistry and drug discovery.

Upstream product

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Downstream Products

• 100493-32-1 2-amino-6-fluorobenzenethiol 
• 100493-33-2 (2S,3S)-3-(2-Amino-6-fluoro-phenylsulfanyl)-2-hydroxy-3-(4-methoxy-phenyl)-propionic acid methyl ester 
• 100601-58-9 (+/-)-trans-(2R,3S)-9-fluoro-2,3-dihydro-3-hydroxy-2-(4'-methoxyphenyl)-1,5-benzothiazepin-4-[5H]-one 
• 100493-29-6 (+/-)-cis-9-fluoro-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one 
• 100601-07-8 (2R,3R)-5-(2-Dimethylamino-ethyl)-9-fluoro-3-hydroxy-2-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one 
• 100601-03-4 Acetic acid (2R,3R)-5-(2-dimethylamino-ethyl)-9-fluoro-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester 

Relevant articles and documents

THERAPEUTIC COMPOUNDS AND COMPOSITIONS

Compounds of general formula (I) and compositions comprising compounds of general formula I that modulate pyruvate kinase are described herein. Also described herein are methods of using the compounds that modulate pyruvate kinase in the treatment of diseases.

THERAPEUTIC COMPOUNDS AND COMPOSITIONS

Compounds of general formula (I) and compositions comprising compounds of general formula (I) that modulate pyruvate kinase are described herein. Also described herein are methods of using the compounds that modulate pyruvate kinase in the treatment of diseases.

Synthesis of Halogen-Substituted 1,5-Benzothiazepine Derivatives and Their Vasodilating and Hypotensive Activities

In an attempt to improve the effectiveness and duration of the action of diltiazem (1), a 1,5-benzothiazepine calcium channel blocker, its derivatives (2) with halogen substituents on the fused benzene ring were synthesized.These compounds were evaluated for their effects on vertebral and coronary blood flows and antihypertensive activity.The structure-activity relationships are discussed.The 8-chloro derivative ((+)-2b), the most potent compound in this series, was selected for clinical evaluation as a cerebral vasodilating and antihypertensive agent.