82635-62-9

Basic information

• Product Name: 1-BENZOYL-3-(3-FLUOROPHENYL)THIOUREA
• Synonyms: 1-BENZOYL-3-(3-FLUOROPHENYL)THIOUREA;N-[(3-Fluorophenyl)carbamothioyl]benzamide
• CAS NO: 82635-62-9
• Molecular Formula: C₁₄H₁₁FN₂OS
• Molecular Weight: 274.31
• Mol File: 82635-62-9.mol
• Article Data: 8

Chemical Properties

• Melting Point: 145-147
• Appearance: /
• CAS DataBase Reference: 1-BENZOYL-3-(3-FLUOROPHENYL)THIOUREA(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BENZOYL-3-(3-FLUOROPHENYL)THIOUREA(82635-62-9)
• EPA Substance Registry System: 1-BENZOYL-3-(3-FLUOROPHENYL)THIOUREA(82635-62-9)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 82635-62-9(Hazardous Substances Data)

Usage

Structure

Thiourea derivative with a benzoyl group and a fluorophenyl group attached to the sulfur atom

Medicinal Chemistry

Due to its pharmacological activities

Drug Development

As a thiourea derivative with potential anti-cancer, anti-viral, and anti-microbial properties

Materials Science

In the development of organic semiconductors and metal complexes

Further Research

Needed to fully understand the potential uses and effects of this chemical compound.

Upstream product

• 372-19-0 meta-fluoroaniline 
• 532-55-8 Benzoyl isothiocyanate 
• 98-88-4 benzoyl chloride 
• 65-85-0 benzoic acid 

Downstream Products

• 458-05-9 1-(3-fluorophenyl)thiourea 
• 324008-17-5 2-{2-[2-(3-fluoro-phenylamino)-thiazol-4-yl]-ethyl}-isoindole-1,3-dione 
• 82635-67-4 N-(3-fluorophenyl)-S-methylisothiourea 
• 20358-07-0 2-amino-5-fluorobenzothiazole 
• 20358-08-1 7-fluorobenzo[d]thiazol-2-amine 

Relevant articles and documents

Synergism of fused bicyclic 2-aminothiazolyl compounds with polymyxin B against: Klebsiella pneumoniae

A series of fused bicyclic 2-aminothiazolyl compounds were synthesized and evaluated for their synergistic effects with polymyxin B (PB) against Klebsiella pneumoniae (SIPI-KPN-1712). Some of the synthesized compounds exhibited synergistic activity. When 4 μg ml-1 compound B1 was combined with PB, it showed potent antibacterial activity, achieving 64-fold reduction of the MIC of PB. Furthermore, compound B1 showed prominent synergistic efficacy in both concentration gradient and time-kill curves in vitro. In addition, B1 combined with PB also exhibited synergistic and partial synergistic effect against E. coli (ATCC25922 and its clinical isolates), Acinetobacter baumannii (ATCC19606 and its clinical isolates), and Pseudomonas aeruginosa (Pae-1399).

Solution-phase microwave assisted parallel synthesis of N,N′-disubstituted thioureas derived from benzoic acid: Biological evaluation and molecular docking studies

An efficient and facile microwave-assisted solution phase parallel synthesis for a 26-member library of N,N′-disubstituted thiourea analogs were accomplished successfully. The reaction time for synthesis of analogs was drastically reduced from a reported 8-12 h to only 10 min. Compounds were more than 95% pure, as characterized by modern analytical techniques, i.e. 1H & 13C NMR and FT-IR. The solid phase structural analysis has also been performed by single crystal XRD analysis. Synthesized compounds were preliminary screened for their in vitro urease inhibition and antifungal activity. Most of the compounds were found to be potent inhibitors of urease. However, the most significant activity was found for 11 with IC 50 of 1.67 μM. The docking scores correlate with the IC 50 values of inhibitors.

One-pot three-step synthesis of 3-aryl-2-benzoylimino-4-thiazolidinones in the ionic liquid [bmim+][PF6-]

3-Aryl-2-acylimino-4-thiazolidinones are efficiently formed in 1-n-butyl-3-methylimidazolium hexafluorophosphate [bmim][PF6] as solvent in a one-pot three-step procedure. The ionic solvent could be recovered and recycled four times with no diminution in yields.