324008-17-5

Basic information

• Product Name: 2-{2-[2-(3-fluoro-phenylamino)-thiazol-4-yl]-ethyl}-isoindole-1,3-dione
• CAS NO: 324008-17-5
• Molecular Weight: 367.403
• Mol File: 324008-17-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-{2-[2-(3-fluoro-phenylamino)-thiazol-4-yl]-ethyl}-isoindole-1,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-{2-[2-(3-fluoro-phenylamino)-thiazol-4-yl]-ethyl}-isoindole-1,3-dione(324008-17-5)
• EPA Substance Registry System: 2-{2-[2-(3-fluoro-phenylamino)-thiazol-4-yl]-ethyl}-isoindole-1,3-dione(324008-17-5)

Safety Data

• Hazardous Substances Data: 324008-17-5(Hazardous Substances Data)

Upstream product

• 51132-00-4 2-(4-bromo-3-oxobutyl)isoindoline-1,3-dione 
• 458-05-9 1-(3-fluorophenyl)thiourea 
• 82635-62-9 1-benzoyl-3-(3-flourophenyl)thiourea 

Relevant articles and documents

Histamine H1 receptor ligands - Part II. Synthesis and in vitro pharmacology of 2-[2-(phenylamino)thiazol-4-yl]ethanamine and 2-(2-benzhydrylthiazol-4-yl)ethanamine derivatives

New 2-[2-(phenylamino)thiazol-4-yl]ethanamine and 2-(2-benzhydrylthiazol-4-yl)ethanamine derivatives were prepared and tested in vitro as H1 receptor antagonists. The compounds with 2-phenylamino substitution with meta-halide substituents at the phenyl ring, showed weak H1-antagonistic activity (pA2: 4.62-5.04) and this activity was completely lost in the case of meta-methyl substituent (pA2 : 4). When the phenylamino group was replaced by benzhydryl groups of classic antihistamines, the resulting compounds exhibited slightly improved H1-antagonistic activity (at the meta-position pA2: 6.38-6.15; at the para-position pA2: 6.04-5.87).