203873-69-2

Basic information

• Product Name: (S)-methyl 2-(N-allyl-4-nitrophenylsulfonamido)-4-methylpentanoate
• Synonyms: (S)-methyl 2-(N-allyl-4-nitrophenylsulfonamido)-4-methylpentanoate
• CAS NO: 203873-69-2
• Molecular Weight: 370.426
• Mol File: 203873-69-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (S)-methyl 2-(N-allyl-4-nitrophenylsulfonamido)-4-methylpentanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-methyl 2-(N-allyl-4-nitrophenylsulfonamido)-4-methylpentanoate(203873-69-2)
• EPA Substance Registry System: (S)-methyl 2-(N-allyl-4-nitrophenylsulfonamido)-4-methylpentanoate(203873-69-2)

Safety Data

• Hazardous Substances Data: 203873-69-2(Hazardous Substances Data)

Upstream product

• 7517-19-3 methyl (L)-leucinate hydrochloride 
• 98-74-8 4-Nitrobenzenesulfonyl chloride 
• 2666-93-5 (S)-Leu-OMe 
• 106-95-6 allyl bromide 
• 203873-66-9 (S)-methyl 4-methyl-2-(4-nitrophenylsulfonamido)pentanoate 

Relevant articles and documents

Site-specific N-alkylation of peptides on the solid phase

A convenient approach, featuring a Mitsunobu reaction, is described for the introduction of an alkyl group at a specific amide function of a peptide on the solid phase. This 'site-specific alkylation' procedure is illustrated with an N-ethyl scan of Leu-enkephalin.

Synthesis of cyclic dipeptides by ring-closing metathesis

Several cyclic dipeptides (4a-g and 9a-c) have been synthesized by 'amide-to-amide' cyclization of 2a-g and 8a-c, respectively, by means of ring-closing metathesis employing the Grubbs ruthenium catalyst. The influence of additives as well as the length of the amide substituent were studied. Best yields were obtained by cyclization in solution with either lithium fluoroacetate or α,α-dichlorotoluene as an additive.