2039-09-0

Basic information

• Product Name: 1H-1,2,4-Triazole, 3,5-bis(4-methoxyphenyl)-
• CAS NO: 2039-09-0
• Molecular Formula: C16H15N3O2
• Molecular Weight: 281.314
• Mol File: 2039-09-0.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 1H-1,2,4-Triazole, 3,5-bis(4-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-1,2,4-Triazole, 3,5-bis(4-methoxyphenyl)-(2039-09-0)
• EPA Substance Registry System: 1H-1,2,4-Triazole, 3,5-bis(4-methoxyphenyl)-(2039-09-0)

Safety Data

• Hazardous Substances Data: 2039-09-0(Hazardous Substances Data)

Usage

Chemical class

Triazole

Appearance

White crystalline solid

Solubility

Insoluble in water, soluble in organic solvents

Structure

1,2,4-triazole ring with two 4-methoxyphenyl groups attached at the 3 and 5 positions

Applications

Pharmaceuticals, agrochemicals, and materials science

Biological and pharmacological activities

Studied for potential properties and effects

Molecular weight

254.29 g/mol

Melting point

Not provided in the material

Boiling point

Not provided in the material

Upstream product

• 93016-27-4 3,5-bis(4-methoxyphenyl)-4-amino-1,2,4-triazole 
• 849-82-1 N,N'-bis-(4-methoxybenzoyl)hydrazine 
• 874-90-8 4-methoxybenzonitrile 
• 5373-87-5 4-methoxybenzamidoxime 
• 3290-99-1 4-methoxybenzoic acid hydrazide 
• 100-07-2 4-methoxy-benzoyl chloride 
• 134322-01-3 p-iodobenzamidine hydrochloride 
• 54998-29-7 ethyl 4-methoxybenzimidate hydrochloride 
• 1670-14-0 benzamidine monohydrochloride 
• 51721-68-7 4-methoxybenzamidine hydrochloride 
• 116377-00-5 bis-(α-chloro-4-methoxy-benzylidene)-hydrazine 
• 6926-51-8 5-(4-methoxyphenyl)-1H-tetrazole 

Downstream Products

• 1447723-65-0 2-(3,5-bis(4-methoxyphenyl)-1H-1,2,4-triazol-1-yl)-1-(4-(pyridin-2-yl)piperazin-1-yl)ethanone 

Relevant articles and documents

A practical base mediated synthesis of 1,2,4-triazoles enabled by a deamination annulation strategy

A rapid and efficient base mediated synthesis of 1,3,5-trisubstituted 1,2,4-triazoles has been developed using the annulation of nitriles with hydrazines, which can be expanded to a wide range of triazoles in good to excellent yields. Ammonia gas is liberated during the reaction, and halo and hetero functional groups as well as free hydroxyl and amino groups are tolerated in this transformation. A variety of alkyl and aryl-substituted nitriles can be functionalized with aromatic and aliphatic hydrazines employing this procedure. This finding provides a practical and useful strategy for the synthesis of various 15N-labeled 1,2,4-triazole derivatives, and two types of mGlu5 receptor pharmaceuticals can be easily assembled in a one-pot manner. This journal is

I2 mediated one-pot synthesis of 1,2,4-triazoles from amidines and imidates

A one-pot facile synthesis of 3,5-disubstituted-1H-1,2,4-triazole derivatives using I2/Cs2CO3 has been described. The method involves readily available inexpensive reagents and is applicable to a wide range of substrates.

Facile synthesis of 3,5-diaryl-1,2,4-triazoles via copper-catalyzed domino nucleophilic substitution/oxidative cyclization using amidines or imidates as substrates

Two methods for the synthesis of 3,5-diaryl-1,2,4-triazoles, both domino reactions, are reported. The first procedure, the Cu(OTf)2-catalyzed reaction between two amidines using NaHCO3 as a base, 1,10-phenanthroline as an additive and K3[Fe(CN)6]/ atmospheric oxygen as the oxidant, delivers 3,5-diaryl-1,2,4-triazoles with yields up to 68%. The second procedure for the synthesis of 3,5-diaryl-1,2,4- triazoles with yields up to 64% rests on the Cu(OTf)2-catalyzed reaction between two imidates and ammonium carbonate. This method features the formation of three bonds in a single synthetic step.