849-82-1

Basic information

• Product Name: 1,2-Bis(4-methoxybenzoyl)hydrazine
• Synonyms: 1,2-Bis(4-methoxybenzoyl)hydrazine;4-methoxy-N'-[(4-methoxyphenyl)carbonyl]benzohydrazide;4-methoxy-N'-(4-methoxybenzoyl)benzohydrazide (non-preferred name)
• CAS NO: 849-82-1
• Molecular Formula: C₁₆H₁₆N₂O₄
• Molecular Weight: 300.30924
• Mol File: 849-82-1.mol
• Article Data: 23

Chemical Properties

• Boiling Point: 568.4°Cat760mmHg
• Flash Point: 297.6°C
• Appearance: /
• Density: 1.22g/cm³
• CAS DataBase Reference: 1,2-Bis(4-methoxybenzoyl)hydrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Bis(4-methoxybenzoyl)hydrazine(849-82-1)
• EPA Substance Registry System: 1,2-Bis(4-methoxybenzoyl)hydrazine(849-82-1)

Safety Data

• Hazardous Substances Data: 849-82-1(Hazardous Substances Data)

Usage

General Description

1,2-Bis(4-methoxybenzoyl)hydrazine is a chemical compound with the molecular formula C18H18N2O4. It is a hydrazine derivative that is commonly used as a building block in organic synthesis. The compound is characterized by two 4-methoxybenzoyl (p-methoxybenzoyl) groups attached to a central hydrazine moiety. 1,2-Bis(4-methoxybenzoyl)hydrazine has been studied for its potential applications in the development of pharmaceuticals and other organic compounds. It is known for its ability to react with various reagents and functional groups, making it a versatile compound in organic chemistry. Additionally, it has attracted interest as a potential building block in the development of diverse functional materials.

Upstream product

• 100-07-2 4-methoxy-benzoyl chloride 
• 3290-99-1 4-methoxybenzoic acid hydrazide 
• 100-09-4 4-methoxybenzoic acid 
• 613-94-5 benzoic acid hydrazide 
• 4231-69-0 1-(4-methoxybenzoyl)-1H-1,2,3-benzotriazole 
• 121-98-2 methyl 4-methoxybenzoate 

Downstream Products

• 38192-16-4 bis-(4-methoxy-benzoyl)-diazene 
• 847-39-2 2,5-bis(4-methoxyphenyl)-1,3,4-oxadiazole 
• 116377-00-5 bis-(α-chloro-4-methoxy-benzylidene)-hydrazine 
• 23359-99-1 4-Methoxy-benzoic acid N'-(4-methoxy-benzyl)-hydrazide 
• 17453-03-1 2,5-Bis-<4-methoxy-phenyl>-1,3,4-thiadiazol 
• 2039-09-0 3,5-bis(4-methoxyphenyl)-1H-1,2,4-triazole 
• 84833-18-1 4-phenyl-3,5-di(p-methoxyphenyl)-1,2,4-triazole 
• 1252660-25-5 2-(4-methoxyphenyl)-5-(4-hydroxyphenyl)-[1,3,4]oxadiazole 
• 1225462-91-8 6-methoxy-2,3-diphenylisoquinolin-1(2H)-one 
• 2039-09-0 3,5-bis(4-methoxyphenyl)-4H-1,2,4-triazole 

Relevant articles and documents

COMPOUND

Compound A compound of formula (I): (I) wherein R1 and R2 are each independently a linear, branched or cyclic C1-20alkyl group; and Ar1 and Ar2 are each independently an aromatic or heteroaromatic gro

Synthesis and in vitro urease inhibitory activity of benzohydrazide derivatives, in silico and kinetic studies

Benzohydrazide derivatives 1–43 were synthesized via “one-pot” reaction and structural characterization of these synthetic derivatives was carried out by different spectroscopic techniques such as 1H NMR and EI-MS. The synthetic molecules were evaluated for their in vitro urease inhibitory activity. All synthetic derivatives showed good inhibitory activities in the range of (IC50 = 0.87 ± 0.31–19.0 ± 0.25 μM) as compared to the standard thiourea (IC50 = 21.25 ± 0.15 μM), except seven compounds 17, 18, 23, 24, 29, 30, and 41 which were found to be inactive. The most active compound of the series was compound 36 (IC50 = 0.87 ± 0.31 μM) having two chloro groups at meta positions of ring A and methoxy group at para position of ring B. The structure–activity relationship (SAR) of the active compounds was established on the basis of different substituents and their positions in the molecules. Kinetic studies of the active compounds revealed that compounds can inhibit enzyme via competitive and noncompetitive modes. In silico study was also performed to understand the binding interactions of the molecules (ligand) with the active site of enzyme.

One-pot synthesis of 1,3,4-thiadiazoles using Vilsmeier reagent as a versatile cyclodehydration agent

A simple and efficient synthetic method for the one-pot synthesis of 1,3,4-thiadiazoles utilizing Vilsmeier reagent was developed. In this method carboxylic acids and hydrazine were converted to 1,3,4-thiadiazoles in the presence of Vilsmeier reagent and Lawesson's reagent. The influence of the thionation reagent, solvent, temperature and time, in this reaction was discussed. The developed methodology for 1,3,4-thiadiazole synthesis has the advantage of simplicity, ambient reaction conditions, easy purification and good to excellent yield of products.