20397-59-5

Basic information

• Product Name: 2-Propenoic acid, 2-fluoro-3-phenyl-, ethyl ester, (2Z)-
• CAS NO: 20397-59-5
• Molecular Formula: C11H11FO2
• Molecular Weight: 194.206
• Mol File: 20397-59-5.mol
• Article Data: 41

Chemical Properties

• CAS DataBase Reference: 2-Propenoic acid, 2-fluoro-3-phenyl-, ethyl ester, (2Z)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, 2-fluoro-3-phenyl-, ethyl ester, (2Z)-(20397-59-5)
• EPA Substance Registry System: 2-Propenoic acid, 2-fluoro-3-phenyl-, ethyl ester, (2Z)-(20397-59-5)

Safety Data

• Hazardous Substances Data: 20397-59-5(Hazardous Substances Data)

Upstream product

• 64-17-5 ethanol 
• 2338-85-4 1-phenyl 1-hydroxy 2.3.3-trifluoro propene ⁽²⁾ 
• 565-53-7 ethyl dibromofluoroacetate 
• 100-52-7 benzaldehyde 
• 128822-96-8 ethyl α-fluoro-α-silylacetate 
• 838-57-3 ethyl 4-nitrobenzoylacetate 
• 1522-41-4 ethyl-2-fluoroacetoacetate 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 133860-74-9 ethyl 2-fluoro-3-(4'-nitrophenyl)-3-oxo-propanoate 
• 1479-22-7 ethyl 2-fluoro-3-oxo-3-phenylpropionate 
• 100-39-0 benzyl bromide 
• 98-88-4 benzoyl chloride 
• 156002-27-6 C₁₄H₁₃FOS 
• 401-55-8 ethyl bromofluoroacetate 

Downstream Products

• 20397-61-9 (Z)-2-fluoro-3-phenylacrylic acid 
• 58041-00-2 (Z)-2-fluoro-3-phenylacrylaldehyde 

Relevant articles and documents

Cis-cinnamic acid analogue, gravitropism modifier (by machine translation)

[Problem] cinnamic acid or cinnamic acid analogue comprising adjusting agent gravitropism cis. [Solution] cinnamic acid and/or cinnamic acid as an active ingredient to adjust gravitropism cis edge agents, cinnamic acid edge is, for example obtained by reacting compounds of the following formula. (In the formula, R is a phenyl group. )Figure 6 [drawing] (by machine translation)

Effect of Fluorination on Skin Sensitization Potential and Fragrant Properties of Cinnamyl Compounds

A series of three α- and three β-fluorinated representatives of the family of cinnamate-derived odorants (cinnamaldehyde (1), cinnamyl alcohol (2), and ethyl cinnamate (3)) as used as fragrance ingredients is described. Olfactive evaluation shows that the

Development of the First Two-Pore Domain Potassium Channel TWIK-Related K+ Channel 1-Selective Agonist Possessing in Vivo Antinociceptive Activity

The TWIK-related K+ channel, TREK-1, has recently emerged as an attractive therapeutic target for the development of a novel class of analgesic drugs, suggesting that activation of TREK-1 could result in pain inhibition. Here, we report the synthesis of a series of substituted acrylic acids (1-54) based on our previous work with caffeate esters. The analogues were evaluated for their ability to modulate TREK-1 channel by electrophysiology and for their in vivo antinociceptive activity (acetic acid-induced writhing and hot plate assays), leading to the identification of a series of novel molecules able to activate TREK-1 and displaying potent antinociceptive activity in vivo. Furyl analogue 36 is the most promising of the series.