2338-85-4

Basic information

• Product Name: 1-phenyl 1-hydroxy 2.3.3-trifluoro propene ⁽²⁾
• Synonyms: 1-phenyl 1-hydroxy 2.3.3-trifluoro propene ⁽²⁾
• CAS NO: 2338-85-4
• Molecular Weight: 188.149
• Mol File: 2338-85-4.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 1-phenyl 1-hydroxy 2.3.3-trifluoro propene ⁽²⁾(CAS DataBase Reference)
• NIST Chemistry Reference: 1-phenyl 1-hydroxy 2.3.3-trifluoro propene ⁽²⁾(2338-85-4)
• EPA Substance Registry System: 1-phenyl 1-hydroxy 2.3.3-trifluoro propene ⁽²⁾(2338-85-4)

Safety Data

• Hazardous Substances Data: 2338-85-4(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 79035-75-9 1,2-bis(dimethylphenylsilyl)-1,1,2,2-tetrafluoroethane 
• 683-78-3 trifluorovinyllithium 
• 212619-47-1 (Z)-2-fluoro-2-trifluoromethylethenyl tosylate 
• 811-97-2 1,1,1,2-tetrafluoroethane 
• 594-19-4 tert.-butyl lithium 
• 917-54-4 methyllithium 
• 109-72-8 n-butyllithium 
• 186824-44-2 1,2-bis(trimethylsilyl)-1,1,2,2-tetrafluoroethane 
• 93629-27-7 dimethylphenyl(1,2,2-trifluoroethenyl)silane 
• 598-73-2 1-bromo-1,2,2-trifluoroethene 
• 79-38-9 Chlorotrifluoroethylene 

Downstream Products

• 111303-10-7 ((Z)-2,3,3-Trifluoro-propenyl)-benzene 
• 55305-87-8 α-Fluor-zimtsaeurediethylamid 
• 20397-61-9 (Z)-2-fluoro-3-phenylacrylic acid 
• 58041-00-2 (Z)-2-fluoro-3-phenylacrylaldehyde 
• 20397-59-5 ethyl (Z)-2-fluoro-3-phenylacrylate 
• 102816-92-2 (Z)-<2,3,3,3-Tetrafluoro-1-propenyl>benzene 
• 66130-99-2 (Z)-2,3-difluoro-1-phenyl-2-propen-1-ol 
• 55305-81-2 α-fluoro-trans-cinnamoyl fluoride 

Relevant articles and documents

Nucleophilic trifluoromethylation with organoboron reagents

Potassium trialkoxy(trifluoromethyl)borates are shown to behave as convenient reagents for nucleophilic trifluoromethylation of non-enolizable aldehydes and N-tosylimines to give CF3-substituted alcohols and N-tosylamines in good yields.

The reactivity of the hydrofluorocarbon 1,1,1,2-tetrafluoroethane (HFC-134a) and related compounds towards base attack. The generation and stability of the tetrafluoroethyl, trifluorovinyl and related anions

Trifluorovinyllithium (CF2 = CFLi) has been successfully synthesised from 1,1,1,2-tetrafluoroethane using n-butyllithium at -78°C in ether. Other bases (LDA, DBU, MeLi, t-BuLi, t-BuOK) were tried with varied success. The stability of the system was dependent on temperature, concentration and solvent system employed. 1-Chloro-2,2,2-trifluoroethane (133a) led to an analogous polyfluorovinyllithium, but 1,1,1-trifluoro- and 1,1,1,2,2,2-hexafluoro- ethane did not.

1,2-Bis(dimethylphenylsilyl)tetrafluoroethane. Application to the trifluorovinylation and tetrafluoroethylenation of carbonyl compounds

The reaction of 1,2-bis(dimethylphenylsilyl)tetrafluoroethane with a small excess of benzaldehyde in the presence of the promoter gave the trifluorovinylated product, 1,1,2-trifluoro-3-phenylpropen-3-ol, selectively. The tetrafluoroethylenated product, 2,2,3,3-tetrafluoro-1,4-diphenylbutane-1,4-diol, was also obtained in benzaldehyde solvent or at low temperatures.