66130-99-2Relevant articles and documents
Highly efficient and stereoselective access to (Z)-α,β- difluoroallyl alcohols and (Z)-α-fluoro-α,β-unsaturated aldehydes based on the reaction of 2,3,3-trifluoro-1-propenyl p- chlorobenzenesulfonate with Grignard reagents
Funabiki, Kazumasa,Fukushima, Yoshitaka,Inagaki, Tomomi,Murata, Eiji,Matsui, Masaki,Shibata, Katsuyoshi
, p. 1913 - 1916 (2007/10/03)
2,3,3-Trifluoro-1-propenyl p=chlorobenzenesulfonate (1), readily available from 2,2,3,3-tetrafluoropropanol, reacted smoothly with various Grignard reagents at 50 °C to afford the corresponding (Z)- α,β-difluoroallyl alcohols 2 in moderate to excellent yields. These alcohols were smoothly hydrolyzed in the presence of a catalytic amount of montmorillonite K10 (Clay) to provide (Z)-α-fluoro-α,β- unsaturated aldehydes 3 in good yields.
