20430-18-6

Basic information

• Product Name: 2-Methyl-2-(p-tolyl)propanoic Acid
• Synonyms: 2-Methyl-2-(p-tolyl)propanoic Acid ;2-Methyl-2-(4-methylphenyl)propanoic acid
• CAS NO: 20430-18-6
• Molecular Formula: C₁₁H₁₄O₂
• Molecular Weight: 178.22766
• Product Categories: Aromatics;Metabolites & Impurities
• Mol File: 20430-18-6.mol
• Article Data: 9

Chemical Properties

• Melting Point: 80-81 °C
• Boiling Point: 290.7°C at 760 mmHg
• Flash Point: 187.8°C
• Appearance: /
• Density: 1.067g/cm³
• Vapor Pressure: 0.000937mmHg at 25°C
• Refractive Index: 1.523
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.49±0.10(Predicted)
• CAS DataBase Reference: 2-Methyl-2-(p-tolyl)propanoic Acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methyl-2-(p-tolyl)propanoic Acid(20430-18-6)
• EPA Substance Registry System: 2-Methyl-2-(p-tolyl)propanoic Acid(20430-18-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 20430-18-6(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 20430-18-6 differently. You can refer to the following data:
1. A metabolite of p-tert-Butyltoluene
2. A metabolite of p-tert-Butyltoluene (TBT).

InChI:InChI=1/C11H14O2/c1-8-4-6-9(7-5-8)11(2,3)10(12)13/h4-7H,1-3H3,(H,12,13)

Upstream product

• 32454-12-9 2-methyl-2-(4-methylphenyl)propionaldehyde 
• 75920-47-7 2-methyl-2-p-tolyl-propionic acid amide 
• 858208-60-3 2-methyl-2-p-tolyl-propionohydroxamic acid 
• 40119-34-4 2-methyl-2-(4-methylphenyl)propionitrile 
• 14062-19-2 p-tolylacetic acid ethyl ester 
• 74-88-4 methyl iodide 
• 7647-01-0 hydrogenchloride 
• 7446-70-0 aluminium trichloride 
• 79-41-4 poly(methacrylic acid) 
• 108-88-3 toluene 
• 64-17-5 ethanol 
• 2947-61-7 (4-methylphenyl)acetonitrile 
• 622-47-9 4-tolylacetic acid 
• 74-83-9 methyl bromide 

Downstream Products

• 24911-30-6 2-(4-carboxy-phenyl)-2-methyl-propionic acid 
• 32454-24-3 2-methyl-2-p-tolyl-propionic acid ethyl ester 
• 40919-17-3 α,α-Dimethyl-4-tolylacetylchlorid 
• 19884-69-6 2,3-Dimethyl-3-(4-methyl-phenyl)-2-chlor-butan 
• 68682-48-4 methyl 2-methyl-2-(4-methylphenyl)propanoate 

Relevant articles and documents

Palladium-Catalyzed Distal m-C-H Functionalization of Arylacetic Acid Derivatives

Herein, we present m-C-H olefination on derivatives of phenylacetic acids by tethering with a simple nitrile-based template through palladium catalysis. Notably, the versatility of the method is evaluated with a wide range of phenylacetic acid derivatives for obtaining the meta-olefination products in fair to excellent yields with outstanding selectivities under mild conditions. Significantly, the present strategy is successfully exemplified for the synthesis of drugs/natural product analogues (naproxen, ibuprofen, paracetamol, and cholesterol).

Palladium(II)-Catalyzed C(sp2)-H Carbonylation of Sterically Hindered Amines with Carbon Monoxide

A palladium-catalyzed, amine-directed C(sp2)-H carbonylation of α,α-disubstituted benzylamine under 1 atm of CO for the facile synthesis of sterically hindered benzolactam has been developed. The key to success is the use of 2,2,6,6-tetramethyl-1-piperidinyloxy as the crucial sole oxidant. The synthetic utility of this transformation has been demonstrated by the first concise synthesis of the natural product spiropachysin-20-one.

NAPHTHALENONE COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, COMPOSITIONS, AND USES THEREOF

Compounds of Formula (I) and Formula (II) are useful as inhibitors of HIF prolyl hydroxylases. Compounds of Formula(I) and Formula (II) have the following structures, where the definitions of the variables are provided herein.