32454-12-9

Basic information

• Product Name: 2-methyl-2-(4-methylphenyl)propionaldehyde
• Synonyms: 2-methyl-2-(4-methylphenyl)propionaldehyde
• CAS NO: 32454-12-9
• Molecular Weight: 162.232
• Mol File: 32454-12-9.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 2-methyl-2-(4-methylphenyl)propionaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-2-(4-methylphenyl)propionaldehyde(32454-12-9)
• EPA Substance Registry System: 2-methyl-2-(4-methylphenyl)propionaldehyde(32454-12-9)

Safety Data

• Hazardous Substances Data: 32454-12-9(Hazardous Substances Data)

Upstream product

• 62134-67-2 [2-Chloro-2-methyl-prop-(E)-ylidene]-isopropyl-amine 
• 108-88-3 toluene 
• 106-38-7 para-bromotoluene 
• 513-42-8 3-hydroxy-2-methyl-1-propene 
• 40119-34-4 2-methyl-2-(4-methylphenyl)propionitrile 
• 22932-03-2 Benzoic acid 2-hydroxy-2-methyl-1-p-tolyl-propyl ester 
• 32454-25-4 2,2-Dimethyl-2-(4-methylphenyl)ethanol 
• 330551-26-3 2-methyl-1-p-tolyl-propane-1,2-diol 
• 5916-22-3 p-methyl-β,β-dimethylstyrene 
• 32454-24-3 2-methyl-2-p-tolyl-propionic acid ethyl ester 
• 488834-29-3 2-methyl-1-(4-methylphenyl)-2-(2,3,5-trimethylphenoxy)propan-1-ol 

Downstream Products

• 1644031-04-8 dimethyl 2-[4-hydroxy-5-methyl-5-(4-methylphenyl)hex-2-ynyl]-2-(prop-2-ynyl)malonate 
• 1644030-63-6 5,5-bis(methoxycarbonyl)-10,10,14-trimethyl-7-phenylsulfonyltricyclo[9.4.0.0^3,8]pentadeca-1⁽¹¹⁾,2,7,12,14-pentaene 
• 1644030-53-4 dimethyl 2-[5-methyl-5-(4-methylphenyl)-2-phenylsulfonylhexa-2,3-dienyl]-2-(prop-2-ynyl)malonate 
• 1186222-33-2 1,1-difluoro-4-methyl-4-(4-methylphenyl)penta-1,2-diene 
• 1186222-23-0 2-bromo-1,1-difluoro-4-methyl-4-(4-methylphenyl)pent-1-en-3-yl acetate 
• 1195-32-0 1-methyl-4-isopropenylbenzene 
• 99-87-6 4-methylisopropylbenzene 
• 50390-51-7 4'-methylisobutyrophenone 
• 59115-82-1 3-para-methylphenyl-2-butanone 
• 142874-62-2 2,2,4,6,7-pentamethyl-3-(4-methylphenyl)-2,3-dihydro-1-benzofuran 
• 20430-18-6 2-methyl-2-(p-tolyl)propanoic acid 
• 734-17-8 2,3-dimethyl-2,3-di-p-tolyl-butane 

Relevant articles and documents

A convenient ring formation of 3-aryl-2,2-dialkyl-2,3-dihydrobenzofurans from phenols and 2-aryl-2,2-dialkylacetaldehydes

A new and simple route for the preparation of 3-aryl-2,2-dialkyl-2,3- dihydrobenzofurans from phenols is described. In the presence of an acid catalyst phenols react with 2-aryl-2,2-dialkylacetaldehydes, prepared in good yield from 2-arylacetonitriles in 2 steps, to give 3-aryl-2,2-dialkyl-2,3- dihydrobenzofurans. Electron-donating substituents were required on the phenols in order to give 3-aryl-2,2-dialkyl-2,3-dihydrobenzofurans in good yield.

GaCl3-catalyzed skeletal rearrangement of α,α, α-trisubstituted aldehydes

(Chemical Equation Presented) GaCl3 is found to be a superior catalyst for the skeletal rearrangement of α,α,α- trisubstituted aldehydes to ketones. The rearrangement can proceed smoothly in the presence of a catalytic amount of GaCl3, and even substrates having no heteroatoms α to the carbonyl group or without steric strains can be used. Double activation of a carbonyl group by two molecules of GaCl 3 was supported on the basis of experimental data and a DFT study.

Reactions of a β-sultam ring with Lewis acids via the C-S bond cleavage

Selective C-S bond cleavage of a β-sultam ring was achieved by the reactions with Lewis acids. Aryl ketones or aldehyde were provided from 3- aryl-β-sultams whereas β-sultams bearing a poorly migratory substituent at C-3 gave trans-1,2,3-oxathiazolidine 2-oxides and/or cis-aziridines. These reactions were influenced by the cation-stabilizing capability of C-4 substituents and by the configuration of the substituents at C-3 and C-4. Some 4-alkenyl-3-aryl-β-sultams underwent tandem intramolecular cyclization to give bicyclo[3.2.1]- and [2.2.1]-γ-sultams via the processes of C-S bond cleavage, 1,2-aryl shift, cation-olefin cyclization and recombination of the sulfonyl anion.