20432-36-4Relevant articles and documents
Novel cyclopentadienyl tricarbonyl complexes of 99mTc mimicking chalcone as potential single-photon emission computed tomography imaging probes for β-amyloid plaques in brain
Li, Zijing,Cui, Mengchao,Dai, Jiapei,Wang, Xuedan,Yu, Pingrong,Yang, Yanping,Jia, Jianhua,Fu, Hualong,Ono, Masahiro,Jia, Hongmei,Saji, Hideo,Liu, Boli
, p. 471 - 482 (2013)
Rhenium and technetium-99m cyclopentadienyl tricarbonyl complexes mimicking the chalcone structure were prepared. These complexes were proved to have affinity to β-amyloid (Aβ) in fluorescent staining on brain sections of Alzheimer's Disease (AD) patient and binding assay using Aβ 1-42 aggregates, with Ki values ranging from 899 to 108 nM as the extension of conjugated π system. In vitro autoradiograpy on sections of transgenic mouse brain confirmed the affinity of [99mTc]5 (K i = 108 nM). In biodistribution, all compounds showed good initial uptakes into the brain and fast blood clearance, while the decreasing of initial brain uptakes correspond to increasing of conjugation length, from 4.10 ± 0.38% ID/g ([99mTc]3) to 1.11 ± 0.34% ID/g ([ 99mTc]5). These small technetium-99m complexes (a promising 99mTc-labeled agent for imaging Aβ plaques in the brain may be feasible.
Benzothiazolium Derivative-Capped Silica Nanocomposites for β-Amyloid ImagingIn Vivo
Ma, Lijun,Yang, Shu,Ma, Yufan,Chen, Yuzhi,Wang, Zhenguo,James, Tony D.,Wang, Xuefei,Wang, Zhuo
, p. 12617 - 12627 (2021/09/30)
Alzheimer’s disease (AD) is a neurodegenerative disease, and β-amyloid (Aβ) is believed to be a causative factor in AD pathology. The abnormal deposition of Aβ is believed to be responsible for progression of AD. In order to facilitate the imaging of Aβin vivo, suitable probe molecules with a near-infrared emission wavelength that can penetrate the blood-brain barrier (BBB) were utilized. The commercial fluorescent probe thioflavin-T (ThT) is used to image Aβ; however, because of its short emission wavelength and poor BBB penetration, ThT can only be usedin vitro. With this research, based on ThT, we design three fluorescent probes (SZIs) having a longer emission wavelength in order to image Aβ aggregates. SZIs with different numbers of double bonds respond to Aβ aggregates. The SZIs have a structure similar to ThT, and as such, the SZIs are also unable to penetrate the BBB. To deal with the problem, we develop nanocomposites (MSN-Lf@SZIs) to deliver SZIs into the brain of AD mouse and image Aβ successfully. These new nanocomposites are able to deliver the dyes into the brain and facilitate Aβ imagingin vivo.
Novel D-A-D based near-infrared probes for the detection of β-amyloid and Tau fibrils in Alzheimer's disease
Li, Yuying,Wang, Kan,Zhou, Kaixiang,Guo, Wentao,Dai, Bin,Liang, Yi,Dai, Jiapei,Cui, Mengchao
supporting information, p. 8717 - 8720 (2018/08/09)
Novel D-π-A-π-D probes were investigated for the detection of Aβ plaques and NFTs. The probes displayed remarkable optical properties, and DADNIR-2 possessed high affinity towards Tau and Aβ aggregates (Kd = 0.41 nM and 1.04 nM, respectively) with certain selectivity. DADNIR-2 could penetrate the BBB and label Aβ plaques in vivo.
The synthesis and evaluation of near-infrared probes with barbituric acid acceptors for in vivo detection of amyloid plaques
Zhou, Kaixiang,Fu, Hualong,Feng, Liang,Cui, Mengchao,Dai, Jiapei,Liu, Boli
supporting information, p. 11665 - 11668 (2015/07/15)
A new array of near-infrared probes containing barbituric acid acceptors has been developed as Aβ imaging agents. These probes displayed long-emission wavelengths and large Stokes shifts, as well as high affinities for Aβ aggregates. In vivo and ex vivo studies demonstrated that BBTOM-3 could intensely label Aβ plaques in the brains of transgenic mice.
