52509-14-5 Usage
Description
(1,3-Dioxolan-2-ylmethyl)triphenylphosphonium bromide is a white to light brown granular powder that serves as a versatile reactant in various chemical syntheses and applications across different industries.
Uses
Used in Pharmaceutical Industry:
(1,3-Dioxolan-2-ylmethyl)triphenylphosphonium bromide is used as a reactant for the synthesis of ketolides methyloxoerythromycins, which exhibit potent antibacterial activity against both macrolide-resistant and susceptible respiratory pathogens.
Used in Analytical Chemistry:
(1,3-Dioxolan-2-ylmethyl)triphenylphosphonium bromide is used as a reactant for the preparation of a ratiometric fluorescent probe, which is specifically designed for the detection of cysteine over homocysteine and glutathione.
Used in Microwave-Assisted Synthesis:
In the field of microwave-assisted synthesis, (1,3-Dioxolan-2-ylmethyl)triphenylphosphonium bromide is utilized as a reactant for the synthesis of KN-93, an inhibitor of calmodulin kinase II.
Used in the Synthesis of s1 Receptor Ligands:
(1,3-Dioxolan-2-ylmethyl)triphenylphosphonium bromide is employed as a reactant in the preparation of fluorinated spirobenzofuran piperidines, which act as s1 receptor ligands.
Used in Antitumor Agent Synthesis:
(1,3-Dioxolan-2-ylmethyl)triphenylphosphonium bromide is also used as a reactant in the synthesis of antitumor agents, contributing to the development of novel cancer treatments.
Used in the Preparation of Indole Derivatives:
(1,3-Dioxolan-2-ylmethyl)triphenylphosphonium bromide is used as a reactant for the regio-selective preparation of indole derivatives through rhodium-catalyzed domino hydroformylation/indolization processes.
Purification Methods
Wash the crystals with Et2O, dry them in a vacuum and recrystallise them from CH2Cl2/dry Et2O to give prisms m 172-174o, which is raised to 191.5-193o on drying at 56o/0.5mm. [Cresp et al. J Chem Soc, Perkin Trans 1 37 1974.]
Check Digit Verification of cas no
The CAS Registry Mumber 52509-14-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,2,5,0 and 9 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 52509-14:
(7*5)+(6*2)+(5*5)+(4*0)+(3*9)+(2*1)+(1*4)=105
105 % 10 = 5
So 52509-14-5 is a valid CAS Registry Number.
InChI:InChI=1/C22H22O2P.BrH/c1-4-10-19(11-5-1)25(18-22-23-16-17-24-22,20-12-6-2-7-13-20)21-14-8-3-9-15-21;/h1-15,22H,16-18H2;1H/q+1;/p-1
52509-14-5Relevant articles and documents
COMPOUND ACTING AS ANTIBIOTICS
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Paragraph 0174; 0176, (2020/12/22)
The present invention provides a novel antibiotic compound represented by the following formula (I), a pharmaceutically acceptable salt thereof, an ester thereof, a prodrug thereof, a solvate thereof, or a deuterated analog thereof, or a stereoisomer thereof. The compound of the present invention exhibits excellent antibacterial activity, especially against Gram bacteria. wherein each group is defined as in the description.
A selective colorimetric and ratiometric fluorescent probe for hydrogen sulfide
Wu, Ming-Yu,Li, Kun,Hou, Ji-Ting,Huang, Zheng,Yu, Xiao-Qi
, p. 8342 - 8347,6 (2012/12/12)
A reaction-based colorimetric and ratiometric fluorescent probe based on an ICT-strategy for selective detection of H2S that exploited the H2S-mediated reduction of nitrocompound to amines was explored. And it displayed high selectivity for H2S over other relevant reactive sulfur, oxygen, nitrogen species and other anions with more than 120 nm blue shift and the change of emission intensity ratio inducted by H2S was over 4750.