204572-02-1

Basic information

• Product Name: {2'-Hydroxy-5'-[6-(4-hydroxy-phenyl)-hexyl]-biphenyl-3-yl}-acetic acid ethyl ester
• Synonyms: {2'-Hydroxy-5'-[6-(4-hydroxy-phenyl)-hexyl]-biphenyl-3-yl}-acetic acid ethyl ester
• CAS NO: 204572-02-1
• Molecular Weight: 432.56
• Mol File: 204572-02-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: {2'-Hydroxy-5'-[6-(4-hydroxy-phenyl)-hexyl]-biphenyl-3-yl}-acetic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: {2'-Hydroxy-5'-[6-(4-hydroxy-phenyl)-hexyl]-biphenyl-3-yl}-acetic acid ethyl ester(204572-02-1)
• EPA Substance Registry System: {2'-Hydroxy-5'-[6-(4-hydroxy-phenyl)-hexyl]-biphenyl-3-yl}-acetic acid ethyl ester(204572-02-1)

Safety Data

• Hazardous Substances Data: 204572-02-1(Hazardous Substances Data)

Upstream product

• 204572-22-5 {2'-Methoxy-5'-[6-(4-methoxy-phenyl)-6-oxo-hexanoyl]-biphenyl-3-yl}-acetic acid ethyl ester 
• 204572-19-0 5-p-Anisoyl-valeroyl-chlorid 
• 29389-23-9 6-(4-methoxyphenyl)-6-oxo-hexanoic acid methyl ester 
• 5537-76-8 6-(4-methoxyphenyl)-6-oxohexanoic acid 
• 627-91-8 adipic acid monomethyl ester 
• 35444-44-1 methyl adipoyl chloride 
• 204572-00-9 {2'-Methoxy-5'-[6-(4-methoxy-phenyl)-hexyl]-biphenyl-3-yl}-acetic acid ethyl ester 

Relevant articles and documents

Novel synthetic inhibitors of selectin-mediated cell adhesion: Synthesis of 1,6-bis[3-(3-carboxymethylphenyl)-4-(2-α-D-mannopyranosyloxy)phenyl] hexane (TBC1269)

Reports of a high-affinity ligand for E-selectin, sialyl di-Lewis(x) (sLe(x)Le(x), 1), motivated us to incorporate modifications to previously reported biphenyl-based inhibitors that would provide additional interactions with the protein. These compounds were assayed for the ability to inhibit the binding of sialyl Lewis(x) (sLe(x), 2) bearing HL-60 cells to E-, P-, and L- selectin fusion proteins. We report that dimeric or trimeric compounds containing multiple components of simple nonoligosaccharide selectin antagonists inhibit sLe(x)-dependent binding with significantly enhanced potency over the monomeric compound. The enhanced potency is consistent with additional binding interactions within a single selectin lectin domain; however, multivalent interaction with multiple lectin domains as a possible alternative cannot be ruled out. Compound 15e (TBC1269) showed optimal in vitro activity from this class of antagonists and is currently under development for use in the treatment of asthma.