5537-76-8

Basic information

• Product Name: 6-(4-METHOXYPHENYL)-6-OXOHEXANOIC ACID
• Synonyms: 6-(4-METHOXYPHENYL)-6-OXOHEXANOIC ACID
• CAS NO: 5537-76-8
• Molecular Formula: C₁₃H₁₆O₄
• Molecular Weight: 236.26
• Mol File: 5537-76-8.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 435.028°C at 760 mmHg
• Flash Point: 166.389°C
• Appearance: /
• Density: 1.149g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.525
• CAS DataBase Reference: 6-(4-METHOXYPHENYL)-6-OXOHEXANOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(4-METHOXYPHENYL)-6-OXOHEXANOIC ACID(5537-76-8)
• EPA Substance Registry System: 6-(4-METHOXYPHENYL)-6-OXOHEXANOIC ACID(5537-76-8)

Safety Data

• Hazardous Substances Data: 5537-76-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C13H16O4/c1-17-11-8-6-10(7-9-11)12(14)4-2-3-5-13(15)16/h6-9H,2-5H2,1H3,(H,15,16)

Upstream product

• 17138-79-3 1-(4-methoxyphenyl)cyclohexanol 
• 20758-60-5 1-(4-methoxyphenyl)cyclohexene 
• 1071-71-2 ethyl 6-chloro-6-oxohexanoate 
• 100-66-3 methoxybenzene 
• 111-50-2 Adipic acid dichloride 
• 20859-19-2 (+/-)-trans-2-(4-methoxyphenyl)cyclohexanol 
• 37087-68-6 2-(4-methoxyphenyl)cyclohexanone 
• 29389-23-9 6-(4-methoxyphenyl)-6-oxo-hexanoic acid methyl ester 
• 7446-70-0 aluminium trichloride 
• 2035-75-8 adipic anhydride 
• 64-19-7 acetic acid 
• 100-07-2 4-methoxy-benzoyl chloride 
• 35444-44-1 methyl adipoyl chloride 
• 627-91-8 adipic acid monomethyl ester 

Downstream Products

• 107228-87-5 6-(4-methoxyphenyl)-hexan-1-oic acid 
• 204572-19-0 5-p-Anisoyl-valeroyl-chlorid 
• 204572-02-1 {2'-Hydroxy-5'-[6-(4-hydroxy-phenyl)-hexyl]-biphenyl-3-yl}-acetic acid ethyl ester 
• 204572-00-9 {2'-Methoxy-5'-[6-(4-methoxy-phenyl)-hexyl]-biphenyl-3-yl}-acetic acid ethyl ester 
• 204572-22-5 {2'-Methoxy-5'-[6-(4-methoxy-phenyl)-6-oxo-hexanoyl]-biphenyl-3-yl}-acetic acid ethyl ester 
• 4354-56-7 6-cyclohexylhexanoic acid 
• 6952-35-8 6-(4-hydroxyphenyl)hexanoic acid 
• 107228-83-1 bis<6-(4-methoxyphenyl)hexanoyl> peroxide 
• 107228-91-1 trans-6-(4-hydroxycyclohexyl)hexanoic acid 
• 107228-93-3 cis-6-(4-hydroxycyclohexyl)hexanoic acid 
• 107228-89-7 6-(4-acetoxycyclohexyl)hexanoic acid 
• 107228-89-7 trans-6-(4-acetoxycyclohexyl)hexanoic acid 
• 107228-75-1 trans-6-<5-(4-hydroxycyclohexyl)pentyl>-2,3-dimethoxy-5-methyl-1,4-benzoquinone 
• 107228-77-3 cis-6-<5-(4-hydroxycyclohexyl)pentyl>-2,3-dimethoxy-5-methyl-1,4-benzoquinone 

Relevant articles and documents

Selective C-C Bond Cleavage of Cycloalkanones by NaNO2/HCl

A novel selective fragmentation of cycloalkanones by NaNO2/HCl has been established. The C-C bond cleavage reaction proceeds smoothly under mild conditions, selectively affording versatile keto acids or oxime acids. The methodology can streamline the synthesis of valuable chiral molecules and isocoumarins from readily available feedstocks.

Azolium/Hydroquinone Organo-Radical Co-Catalysis: Aerobic C?C-Bond Cleavage in Ketones

Organo-radical catalysts have recently attracted great interest, and the development of this field can be expected to broaden the applications of organocatalysis. Herein, the first example of a radical-generating system is reported that does not require any photoirradiation, radical initiators, or preactivated substrates. The oxidative C?C-bond cleavage of 2-substituted cyclohexanones was achieved using an azolium salt and a hydroquinone as co-catalysts. A catalytic mechanism was proposed based on the results of diffusion-ordered spectroscopy and cyclic voltammetry measurements, as well as computational studies.

Novel synthetic inhibitors of selectin-mediated cell adhesion: Synthesis of 1,6-bis[3-(3-carboxymethylphenyl)-4-(2-α-D-mannopyranosyloxy)phenyl] hexane (TBC1269)

Reports of a high-affinity ligand for E-selectin, sialyl di-Lewis(x) (sLe(x)Le(x), 1), motivated us to incorporate modifications to previously reported biphenyl-based inhibitors that would provide additional interactions with the protein. These compounds were assayed for the ability to inhibit the binding of sialyl Lewis(x) (sLe(x), 2) bearing HL-60 cells to E-, P-, and L- selectin fusion proteins. We report that dimeric or trimeric compounds containing multiple components of simple nonoligosaccharide selectin antagonists inhibit sLe(x)-dependent binding with significantly enhanced potency over the monomeric compound. The enhanced potency is consistent with additional binding interactions within a single selectin lectin domain; however, multivalent interaction with multiple lectin domains as a possible alternative cannot be ruled out. Compound 15e (TBC1269) showed optimal in vitro activity from this class of antagonists and is currently under development for use in the treatment of asthma.