20859-19-2

Basic information

• Product Name: Cyclohexanol, 2-(4-methoxyphenyl)-, trans-
• CAS NO: 20859-19-2
• Molecular Formula: C13H18O2
• Molecular Weight: 206.285
• Mol File: 20859-19-2.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Cyclohexanol, 2-(4-methoxyphenyl)-, trans-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanol, 2-(4-methoxyphenyl)-, trans-(20859-19-2)
• EPA Substance Registry System: Cyclohexanol, 2-(4-methoxyphenyl)-, trans-(20859-19-2)

Safety Data

• Hazardous Substances Data: 20859-19-2(Hazardous Substances Data)

Upstream product

• 43050-21-1 2-(4'-Methoxyphenyl)-3-hydroxy-cyclohexen 
• 822-87-7 2-Chlorocyclohexanone 
• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 286-20-4 cyclohexane-1,2-epoxide 
• 20859-19-2 (+/-)-trans-2-(4-methoxyphenyl)cyclohexanol 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 37087-68-6 2-(4-methoxyphenyl)cyclohexanone 
• 108-94-1 cyclohexanone 
• 17138-79-3 1-(4-methoxyphenyl)cyclohexanol 
• 20758-60-5 1-(4-methoxyphenyl)cyclohexene 

Downstream Products

• 20859-19-2 (+/-)-cis-2-(4-Methoxy-phenyl)-cyclohexanol 
• 22720-25-8 (1S,2S)-2-(4-Methoxy-phenyl)-cyclohexylamine 
• 152140-46-0 (lR,2S)-trans-2-(p-methoxyphenyl)cyclohexan-1-ol 
• 146744-35-6 (1S,2R)-trans-2-(4-methoxyphenyl)cyclohexanol 
• 377775-90-1 3β-acetoxy-5-etienic acid (1S,2R)-2-naphthyl ester 

Relevant articles and documents

Palladium-catalyzed asymmetric hydrogenation of 2-aryl cyclic ketones for the synthesis oftranscycloalkanols through dynamic kinetic resolution under acidic conditions

The first efficient palladium-catalyzed asymmetric hydrogenation of 2-aryl cyclic ketones has been described through dynamic kinetic resolution under acidic conditions, providing a facile access to chiraltranscycloalkanol derivatives with excellent enantioselectivities.

α-iodocycloalkenones: Synthesis of (±)-epibatidine

A synthesis of the non-opiate analgesic alkaloid epibatidine was achieved in 13 steps and 13% Overall yield starting from 1,3-cyclohexadiene using in a key step a modified Stille coupling reaction on an α- iodocyclohexenone.

Asymmetric synthesis of CDP840 by Jacobsen epoxidation. An unusual syn selective reduction of an epoxide

An asymmetric synthesis of the PDE IV inhibitor, CDP840 (3) is reported. The absolute stereochemistry was controlled by a Jacobsen epoxidation of the Z triaryl olefin 8 (89% ee) or the E triaryl olefin 9 (48% ee). The disparate results in stereocontrol were interpreted in terms of the 'skewed side-on approach model' proposed by Jacobsen. LiBH4 · BH3 reduction of the epoxides was found to proceed with retention of configuration.