20469-63-0

Basic information

• Product Name: 2,4-Dimethoxyiodobenzene
• Synonyms: 2,4-DIMETHOXY-1-IODOBENZENE;2,4-DIMETHOXYIODOBENZENE;1-IODO-2,4-DIMETHOXYBENZENE;1,3-DIMETHOXY-4-IODOBENZENE;Dimethoxyiodobenzene;4-IODO-1,3-DIMETHOXYBENZENE;2,4-Dimethoxyphenyl iodide;3-Methoxy-4-iodoanisole
• CAS NO: 20469-63-0
• Molecular Formula: C₈H₉IO₂
• Molecular Weight: 264.06
• Product Categories: Aromatic Halides (substituted);Anisoles, Alkyloxy Compounds & Phenylacetates;Iodine Compounds;Ethers;Organic Building Blocks;Oxygen Compounds
• Mol File: 20469-63-0.mol
• Article Data: 15

Chemical Properties

• Melting Point: 37-41 °C(lit.)
• Boiling Point: 135°C 14mm
• Flash Point: >230 °F
• Appearance: light yellow crystal
• Density: 1.655 g/cm³
• Vapor Pressure: 0.00515mmHg at 25°C
• Refractive Index: 1.6100
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility: soluble in Methanol
• Sensitive: Light Sensitive
• BRN: 1945135
• CAS DataBase Reference: 2,4-Dimethoxyiodobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Dimethoxyiodobenzene(20469-63-0)
• EPA Substance Registry System: 2,4-Dimethoxyiodobenzene(20469-63-0)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/38
• Safety Statements: 26-36/37/39-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 20469-63-0(Hazardous Substances Data)

Usage

Chemical Properties

lightyellowcrystallinemas

Synthesis Reference(s)

Tetrahedron Letters, 40, p. 6051, 1999 DOI: 10.1016/S0040-4039(99)01236-8

InChI:InChI=1/C8H9IO2/c1-10-6-3-4-7(9)8(5-6)11-2/h3-5H,1-2H3

Upstream product

• 51560-17-9 1,5-diiodo-2,4-dimethoxy-benzene 
• 151-10-0 1,3-Dimethoxybenzene 
• 116810-62-9 <<3-<(6-chloropyridazin-3-yl)methyl>-4-methoxyphenyl>>-(2,4-dimethoxyphenyl)iodonium trifluoroacetate 
• 105189-44-4 3,5-dibromo-N-trifluoroacetyl-L-tyrosine methyl ester 
• 2735-04-8 2,4-Dimethoxyaniline 
• 64-17-5 ethanol 
• 7553-56-2 iodine 
• 2265-93-2 2,4-difluoro-1-iodobenzene 
• 865-33-8 potassium methanolate 
• 91-52-1 2,4 dimethoxybenzoic acid 
• 1466-76-8 2-6-dimethoxybenzoic acid 

Downstream Products

• 51560-17-9 1,5-diiodo-2,4-dimethoxy-benzene 
• 151-10-0 1,3-Dimethoxybenzene 
• 112221-47-3 (2,4-dimethoxy-phenyl)-(3,5-dimethoxy-phenyl)-ether 
• 108474-22-2 2',4'-dimethoxy-biphenyl-4-carboxylic acid 
• 5667-52-7 2,4-dimethoxy-1-(phenylsulfanyl)benzene 
• 5667-53-8 (2,4-dimethoxyphenyl)(4-methylphenyl)sulfane 
• 529-28-2 4-iodoanisol 
• 696-62-8 para-iodoanisole 
• 141957-84-8 4-(2,4-Dimethoxy-phenyl)-3,8,10-trimethoxy-6H-benzo[c]chromene 
• 86489-60-3 2-(2,4-Dimethoxy-phenyl)-malononitrile 
• 157953-17-8 4-(2,4-Dimethoxy-phenyl)-2-methyl-but-3-yn-2-ol 
• 93435-39-3 6,2',4'-Trimethoxy-biphenyl-carbonsaeure-⁽³⁾ 
• 53084-00-7 1-(2,4-Dimethoxy-phenyl)-4-methyl-cyclohexanol 
• 78594-17-9 bis(2,4-dimethoxyphenyl)acetylene 

Relevant articles and documents

Decarboxylative Suzuki-Miyaura coupling of (hetero)aromatic carboxylic acids using iodine as the terminal oxidant

A novel methodology for the decarboxylative Suzuki-Miyaura-type coupling has been established. This process uses iodine or a bromine source as both the decarboxylation mediator and the terminal oxidant, thus avoiding the need for stoichiometric amounts of transition metal salts previously required. Our new protocol allows for the construction of valuable biaryl architectures through the coupling of (hetero)aromatic carboxylic acids with arylboronic acids. The scope of this decarboxylative Suzuki reaction has been greatly diversified, allowing for previously inaccessible non-ortho-substituted aromatic acids to undergo this transformation. The procedure also benefits from low catalyst loadings and the absence of stoichiometric transition metal additives.

Method for synthesizing mono-aryl iodide or di-aryl iodide based on aromatic hydrocarbon carboxylic acid decarboxylic reaction

The invention discloses a method for synthesizing mono-aryl iodide or di-aryl iodide based on aromatic hydrocarbon carboxylic acid decarboxylic reaction. The method is characterized in that under a protective atmosphere, carrying out one-pot reaction on a

Decarboxylative Halogenation and Cyanation of Electron-Deficient Aryl Carboxylic Acids via Cu Mediator as Well as Electron-Rich Ones through Pd Catalyst under Aerobic Conditions

Simple strategies for decarboxylative functionalizations of electron-deficient benzoic acids via using Cu(I) as promoter and electron-rich ones by employing Pd(II) as catalyst under aerobic conditions have been established, which lead to smooth synthesis of aryl halides (-I, Br, and Cl) through the decarboxylative functionalization of benzoic acids with readily available halogen sources CuX (X = I, Br, Cl), and easy preparation of benzonitriles from decarboxylative cyanation of aryl carboxylic acids with nontoxic and low-cost K4Fe(CN)6 under an oxygen atmosphere for the first time.