20497-95-4

Basic information

• Product Name: METHYL 3-NITROPROPIONATE 97
• Synonyms: METHYL 3-NITROPROPIONATE 97;METHYL 3-NITROPROPIONATE 97%;Methyl 3-nitropropionate;Methyl 3-Nitropropanoate
• CAS NO: 20497-95-4
• Molecular Formula: C₄H₇NO₄
• Molecular Weight: 133.10268
• Mol File: 20497-95-4.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 68 °C/1 mmHg(lit.)
• Flash Point: 110 °C
• Appearance: /
• Density: 1.249 g/mL at 25 °C(lit.)
• Refractive Index: n20/D 1.4350(lit.)
• PKA: 7.67±0.29(Predicted)
• CAS DataBase Reference: METHYL 3-NITROPROPIONATE 97(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 3-NITROPROPIONATE 97(20497-95-4)
• EPA Substance Registry System: METHYL 3-NITROPROPIONATE 97(20497-95-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 20497-95-4(Hazardous Substances Data)

Upstream product

• 3395-91-3 Methyl 3-bromopropionate 
• 186581-53-3 diazomethane 
• 504-88-1 3-nitropropionic acid 
• 67-56-1 methanol 
• 292638-85-8 acrylic acid methyl ester 
• 5199-50-8 methyl 2-iodoacetate 

Downstream Products

• 50692-78-9 methyl 3-[[(2R)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]propanoate 
• 63819-86-3 Methyl 3-nitro-2-(3-oxocyclohexyl)propanoate 
• 126158-19-8 cis-4-<2-<(methoxycarbonyl)methyl>-2-nitrovinyl>-1-(4-methoxyphenyl)-3-phthalimidoazetidin-2-one 
• 100423-75-4 (3S,4S,5R)-5-Benzyloxy-4-hydroxy-3-nitro-hexanoic acid methyl ester 
• 100423-76-5 (3S,4R,5R)-5-Benzyloxy-4-hydroxy-3-nitro-hexanoic acid methyl ester 
• 100423-77-6 (3R,4S,5R)-5-Benzyloxy-4-hydroxy-3-nitro-hexanoic acid methyl ester 
• 146073-36-1 methyl (E)-3-nitro-4-(1-phenylsulfonyl-2-pyrrolyl)-3-butenoate 
• 4138-35-6 methyl 3-aminopropanoate 
• 82588-88-3 Methyl 2-(1-hydroxycyclohexyl)-3-nitro-propanoate 
• 63819-85-2 (RS)-2-benzyl-3-nitropropanoic acid methyl ester 
• 82588-83-8 methyl 3-hydroxy-2-(nitromethyl)-3-phenylpropanoate 
• 82266-95-3 (+)-lyxo-3-(Benzoylamino)-2,3,6-trideoxyhexanoic acid γ-lactone 
• 76512-86-2 3-benzoylamino-2,3,6-trideoxyhexono-L-ribo-γ-lactone 
• 82588-86-1 Methyl 3-(3,4-dimethoxyphenyl)-3-hydroxy-2-(nitromethyl)propanoate 

Relevant articles and documents

An expeditious synthesis of 3-nitropropionic acid and its ethyl and methyl esters

The synthesis to 3-nitropropionic acid 1 was easily accomplished, in two steps, from commercially available acrolein in 60% yield. The ethyl and methyl esters of 1 were also obtained.

SUBSTITUTED PYRROLIDINE AMIDES IV

The invention relates to compounds according to general formula (I), which act as modulators of the glucocorticoid receptor and can be used in the treatment and/or prophylaxis of disorders which are at least partially mediated by the glucocorticoid receptor.

Nitroalkylation of alkyl iodides via radical reaction of silyl nitronates

Abstract: Radical reaction of alkyl iodides with phenylsulfonyl substituted silyl nitronates in the presence of hexamethylditin at 300 nm afforded C-alkylated nitro compounds.